SML0294

ABL127

≥98% (HPLC)

• 別名: (3R)-1,2-Dicarboxylic acid, 3-cyclopentyl-4-oxo-3-phenyl-1,2-diazetidine 1,2-dimethyl ester, (3R)-Dimethyl 3-cyclopentyl-4-oxo-3-phenyl-1,2-diazetidine-1,2-dicarboxylate, CID24856225
• 実験式（ヒル表記法）: C₁₇H₂₀N₂O₅
• CAS番号: 1073529-41-5
• 分子量: 332.35
• MDL番号: MFCD28053514
• UNSPSCコード: 12352200
• PubChem Substance ID: 329825301
• NACRES: NA.77

特性

• 品質水準: 100
• アッセイ: ≥98% (HPLC)
• フォーム: film
• 色: colorless
• 溶解性: DMSO: ≥5 mg/mL
• 保管温度: 2-8°C
• SMILES記法: O=C1[C@](C2=CC=CC=C2)(C3CCCC3)N(C(OC)=O)N1C(OC)=O
• InChI: 1S/C17H20N2O5/c1-23-15(21)18-14(20)17(13-10-6-7-11-13,19(18)16(22)24-2)12-8-4-3-5-9-12/h3-5,8-9,13H,6-7,10-11H2,1-2H3/t17-/m0/s1
• InChI Key: ZRHWCAFAIHTQKD-KRWDZBQOSA-N

詳細

生物化学的／生理学的作用

ABL127 is a potent and selective inhibitor of Protein phosphatase methylesterase-1 (PME-1 or PPME-1).

ABL127 is a potent and selective inhibitor of Protein phosphatase methylesterase-1 (PME-1 or PPME-1). IC50 values were 11.1 nM and 6.4 nM in MDA-MB-231 and HEK 293T cells with no activity detected against >50 other serine hydrolases. PME-1 regulates the methylesterification state of protein phosphatase 2A (PP2A) and is implicated in cancer and neurodegeneration.

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable