SML0222

TVP1022

≥98% (HPLC)

• 別名: (1S)-2,3-Dihydro-N-2-propyn-1-yl-1H-inden-1-amine, (S)-Rasagiline, S-(-)-N-Propargyl-1-aminoindan
• 実験式（ヒル表記法）: C₁₂H₁₃N
• CAS番号: 185517-74-2
• 分子量: 171.24
• MDL番号: MFCD09029306
• UNSPSCコード: 12352200
• PubChem Substance ID: 329825241
• NACRES: NA.77

特性

• アッセイ: ≥98% (HPLC)
• 形状: powder
• 溶解性: DMSO: ≥15 mg/mL
• 保管温度: 2-8°C
• SMILES記法: C#CCN[C@H]1CCc2ccccc12
• InChI: 1S/C12H13N/c1-2-9-13-12-8-7-10-5-3-4-6-11(10)12/h1,3-6,12-13H,7-9H2/t12-/m0/s1
• InChI Key: RUOKEQAAGRXIBM-LBPRGKRZSA-N

詳細

生物化学的／生理学的作用

TVP1022, the S-isomer of rasagiline, an anti-Parkinson drug, appears to have the same neuroprotective activity as the R-isomer, but is 1000-fold less active as an MAO-B inhibitor. TVP1022, a neuroprotective and cytoprotective molecule, is also cardioprotective in rat models. Its activity is believed to involve stabilization of mitochondrial membrane potential, induction of Bcl-2 and activation of the PKC signalling pathway, enhancing the phosphorylation of protein kinase C and glycogen synthase kinase-3β.

安全性情報

• ピクトグラム: GHS07,GHS09
• シグナルワード: Warning
• 危険有害性情報: H302,H400
• 注意書き: P273 - P301 + P312 + P330
• 危険有害性の分類: Acute Tox. 4 Oral - Aquatic Acute 1
• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable