SML0177

AUDA

≥98% (HPLC)

• 別名: 12-[[(tricyclo[3.3.1.13,7]dec-1-ylamino)carbonyl]amino]-dodecanoic acid
• 実験式（ヒル表記法）: C₂₃H₄₀N₂O₃
• CAS番号: 479413-70-2
• 分子量: 392.58
• MDL番号: MFCD12912267
• UNSPSCコード: 12352200
• PubChem Substance ID: 329825206
• NACRES: NA.77

特性

• アッセイ: ≥98% (HPLC)
• 形状: powder
• 色: white to beige
• 溶解性: DMSO: ≥10 mg/mL at warmed to 60 °C
• 保管温度: −20°C
• SMILES記法: OC(=O)CCCCCCCCCCCNC(=O)NC12C[C@@H]3C[C@@H](C[C@@H](C3)C1)C2
• InChI: 1S/C23H40N2O3/c26-21(27)10-8-6-4-2-1-3-5-7-9-11-24-22(28)25-23-15-18-12-19(16-23)14-20(13-18)17-23/h18-20H,1-17H2,(H,26,27)(H2,24,25,28)/t18-,19+,20-,23-
• InChI Key: XLGSEOAVLVTJDH-UKBVAGSOSA-N

詳細

アプリケーション

AUDA has been used in the inhibition of epoxide hydrolase in human macrophages and in inhibition of tumor necrosis factor α (TNF-α)- induced phosphorylation in human aortic smooth muscle cells.

AUDA may be used in soluble epoxide hydrolase-mediated cell signaling studies.

生物化学的／生理学的作用

Inhibition of soluble epoxide hydrolase by AUDA inhibits the metabolism of epoxyeicosatrienoic acids (EETs) and protects end-organs against the damaging effects of salt-sensitive hypertension. AUDA also renders protection against myocardial ischemia-reperfusion injury and cerebral ischemia.

AUDA is a potent inhibitor of soluble epoxide hydrolase

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable