SMB01026

Mosloflavon

≥90% (LC/MS-ELSD)

• 別名: 5-Hydroxy-6,7-dimethoxyflavone
• 実験式（ヒル表記法）: C₁₇H₁₄O₅
• CAS番号: 740-33-0
• 分子量: 298.29
• MDL番号: MFCD00601540
• UNSPSCコード: 12352205
• NACRES: NA.25

特性

• 由来生物: plant
• アッセイ: ≥90% (LC/MS-ELSD)
• 形状: solid
• 分子量: 298.29
• 溶解性: water: slightly soluble
• アプリケーション: metabolomics; vitamins, nutraceuticals, and natural products
• 保管温度: −20°C
• InChI: 1S/C17H14O5/c1-20-14-9-13-15(16(19)17(14)21-2)11(18)8-12(22-13)10-6-4-3-5-7-10/h3-9,19H,1-2H3
• InChI Key: SIVAITYPYQQYAP-UHFFFAOYSA-N

詳細

詳細

Mosloflavon, a 2-hydroxyflavanone, is a bioactive natural compound commonly derived from plants such as Mosla soochouensis, Desmos dumosus, Muntingia calabura, Cryptocarya chinensis, and Phonus arborescens. Extensive research indicates that this natural metabolite acts as an inhibitor may possess a wide range of biological activities, including anti-inflammatory, antioxidant, antiviral, antifungal, immunomodulatory, anti-infection, and anti-hypoxic properties.

アプリケーション

Mosloflavon is a natural product derived from plant source that finds application in compound screening libraries, metabolomics, phytochemical, and pharmaceutical research.

生物化学的／生理学的作用

Mosloflavanone exhibits potent anti-EV71 activity by reducing visible cytopathic effects and suppressing virus replication during the initial infection phase. It also hinders the expression of the viral VP2 protein, thereby impeding viral capsid protein synthesis. Additionally, Mosloflavone demonstrates significant anti-inflammatory potential through the inhibition of TNF-α and IL-1β, with IC50 values of 16.4 μM and 6.4 μM, respectively. It shows a dose-dependent reduction in TNF-α, IL-1β, and iNOS levels in the supernatant of the mouse macrophage cell line J774A. This compound holds promise as a foundational element in the quest for treatments targeting inflammatory and immunomodulatory diseases.

特徴および利点

• Suitable for Biochemical and Biomedical research
• Versatile and adaptable for wide variety of laboratory and research applications

その他情報

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安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable