SMB00928

4′-Hydroxy carvedilol

• 別名: 4′-Hydroxy carvedilol, 4′-Hydroxyphenyl carvedilol, 4′-OH carvedilol, 4′OH-CVD, 4-(2-(3-(9H-carbazol-4-yloxy)-2-hydroxypropylamino)ethoxy)-3-methoxyphenol, 4-[2-[[3-(9H-Carbazol-4-yloxy)-2-hydroxypropyl]amino]ethoxy]-3-methoxyphenol, 4OHC, BM 140686, BM 14686, Carvedilol metabolite M4
• 実験式（ヒル表記法）: C₂₄H₂₆N₂O₅
• CAS番号: 142227-49-4
• 分子量: 422.47
• UNSPSCコード: 12352200
• NACRES: NA.25

特性

• アッセイ: ≥95%
• 品質水準: 100
• 形状: solid
• 色: off-white to white
• 保管温度: 2-8°C
• InChI: 1S/C24H26N2O5/c1-29-23-13-16(27)9-10-21(23)30-12-11-25-14-17(28)15-31-22-8-4-7-20-24(22)18-5-2-3-6-19(18)26-20/h2-10,13,17,25-28H,11-12,14-15H2,1H3
• InChI Key: ZCJHEORDHXCJNB-UHFFFAOYSA-N

詳細

詳細

Carvedilol is a β- and α1-adrenoreceptor blocker for the treatment of hypertension and congestive heart failure (CHF). The drug is metabolized by CYP2D6 (to 4′-OH and 5′-OH), CYP2C9 (to O-desmethyl), CYP1A2 (to 8-OH). It is also oxidized to 1-OH carvedilol, but the enzyme involved is not yet clear. These metabolites are useful markers for studying and monitoring the activities of cytochrome metabolizing enzymes. M4 metabolite (4′-OH), but not M2 or M5, is most likely to contribute to total β-adrenoceptor blocking activity due to its higher potency.

アプリケーション

Metabolomics

その他情報

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安全性情報

• ピクトグラム: GHS08,GHS09
• シグナルワード: Warning
• 危険有害性情報: H373,H411
• 注意書き: P260 - P273 - P314 - P391 - P501
• 危険有害性の分類: Aquatic Chronic 2 - STOT RE 2
• ターゲットの組織: Liver,spleen,Uterus (including cervix),Adrenal gland
• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable