SCP0216

プラスミノーゲンアクチベーター基質

• 実験式（ヒル表記法）: C₂₈H₄₁N₇O₅
• 分子量: 555.67
• UNSPSCコード: 12352202
• NACRES: NA.32

特性

• アッセイ: ≥95% (HPLC)
• 形状: lyophilized
• 組成: Peptide Content, ≥80%
• 保管条件: protect from light
• 保管温度: −20°C

詳細

Amino Acid Sequence

BOC-Val-Gly-Arg-βNA

アプリケーション

Plasminogen Activator Substrate has been used as a fluorogenic thrombin substrate to measure the fluorescence released by cleavage of the thrombin substrate to assess the functional activity of the mannose-binding lectin–mannose-associated serine protease (MBL-MASP) complex.

Plasminogen Activator is a serine protease that coverts plasminogen into plasmin. Plasminogen activator may be detected using VGR peptide substrates such a BOC-VGR-βNA and Boc-Val-Gly-Arg-AMC (VGR).

生物化学的／生理学的作用

Plasminogen activator (PA) is used to cure life-threatening coronary and cerebrovascular blockages. The important role of the PA system is to convert the inactive plasminogen to plasmin. However, it also plays a vital role in embryogenesis, cell migration, wound healing, inflammatory response, and apoptotic cell death. The PA system is also involved in tumor growth, angiogenesis, tumor cell invasion, migration, and metastasis in cancer patients.

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable