SAB5700569

Anti-Phospho-ABL1-Y412 antibody produced in rabbit

• 別名: ABL, ABL1, CHDSKM, JTK7, bcr/abl, c-ABL, c-ABL1, c-Abl, p150, v-abl
• UNSPSCコード: 12352203
• NACRES: NA.41

特性

• 由来生物: rabbit
• 品質水準: 100
• 抗体製品の状態: affinity isolated antibody
• 抗体製品タイプ: primary antibodies
• クローン: polyclonal
• 形状: buffered aqueous solution
• 分子量: 123
• 化学種の反応性: rat, mouse, human
• 濃度: 0.51mg/ml
• テクニック: immunohistochemistry: 1:50-1:200; western blot: 1:500-1:2000
• UniProtアクセッション番号: P00519
• 輸送温度: wet ice
• 保管温度: −20°C
• ターゲットの翻訳後修飾: phosphorylation (pTyr412)
• 遺伝子情報: human ... ABL1 (25)

詳細

詳細

This gene is a protooncogene that encodes a protein tyrosine kinase involved in a variety of cellular processes, including cell division, adhesion, differentiation, and response to stress. The activity of the protein is negatively regulated by its SH3 domain, whereby deletion of the region encoding this domain results in an oncogene. The ubiquitously expressed protein has DNA-binding activity that is regulated by CDC2-mediated phosphorylation, suggesting a cell cycle function. This gene has been found fused to a variety of translocation partner genes in various leukemias, most notably the t(9;22) translocation that results in a fusion with the 5′ end of the breakpoint cluster region gene (BCR; MIM:151410). Alternative splicing of this gene results in two transcript variants, which contain alternative first exons that are spliced to the remaining common exons.

免疫原

A phospho synthetic peptide corresponding to residues surrounding Y412 of human ABL1.

物理的形状

PBS with 0.02% sodium azide,50% glycerol,pH7.3.

保管および安定性

Store at -20℃. Avoid freeze / thaw cycles.

安全性情報

• 保管分類コード: 12 - Non Combustible Liquids
• WGK: WGK 1
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable