SAB4503824

Anti-phospho-p130 Cas (pTyr⁴¹⁰) antibody produced in rabbit

affinity isolated antibody

• UNSPSCコード: 12352203
• NACRES: NA.41

特性

• 由来生物: rabbit
• 結合体: unconjugated
• 抗体製品の状態: affinity isolated antibody
• 抗体製品タイプ: primary antibodies
• クローン: polyclonal
• 形状: buffered aqueous solution
• 分子量: antigen 93 kDa
• 化学種の反応性: mouse, rat, human
• 濃度: ~1 mg/mL
• テクニック: ELISA: 1:5000; immunohistochemistry: 1:50-1:100; western blot: 1:500-1:1000
• NCBIアクセッション番号: P56945
• UniProtアクセッション番号: P56945
• 輸送温度: wet ice
• 保管温度: −20°C
• ターゲットの翻訳後修飾: phosphorylation (pTyr410)
• 遺伝子情報: human ... BCAR1(9564)

詳細

詳細

Breast cancer antiestrogen resistance 1 (BCAR1), also known as p130 Cas, is encoded by the gene mapped to human chromosome 16q23. BCAR1 belongs to Cas (Crk-associated substrate) protein family. The protein is characterized with an amino-terminal Src homology 3 (SH3) domain, a Src-binding domain, a large substrate domain, and a helix-loop-helix domain.

免疫原

The antiserum was produced against synthesized peptide derived from human p130 Cas around the phosphorylation site of Tyr410.

Immunogen Range: 376-425

生物化学的／生理学的作用

Breast cancer antiestrogen resistance 1 (BCAR1), also known as p130 Cas, plays a vital role in various cellular processes such as migration, adhesion, cytoskeleton reorganization host-pathogen interaction, survival, proliferation, transformation, and possibly metastasis. It is associated with the growth factor receptor EGFR and the metastasis suppressor KAI1, in vitro. Overexpression of BCAR1 in localized prostate cancers (LPC) suggests that this protein has potential as a marker for both prognosis and treatment. It is also considered to be a potential marker for breast cancer. Neural precursor cell expressed developmentally down-regulated protein 9 (NEDD-9) and BCAR1, via SRC, promote removal of E-Cadherin from cell membrane, and trigger E-cadherin degradation.

特徴および利点

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

物理的形状

ウサギIgGのPBS溶液（Mg2+およびCa2+を含まず）、pH 7.4、150 mM NaCl、0.02％ アジ化ナトリウム、50％ グリセロール

免責事項

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全性情報

• 保管分類コード: 10 - Combustible liquids
• WGK: WGK 1
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable