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由来生物
rabbit
品質水準
抗体製品の状態
affinity isolated antibody
抗体製品タイプ
primary antibodies
クローン
polyclonal
フォーム
buffered aqueous solution
分子量
55 kDa
濃度
1 mg/mL
テクニック
western blot: 1:1000-1:5000 (Cell Lysate)
アイソタイプ
IgG
輸送温度
wet ice
保管温度
−20°C
ターゲットの翻訳後修飾
unmodified
詳細
c-Myc (v-myc avian myelocytomatosis viral oncogene homolog) is a transcription factor, which is coded by MYC gene. It was first described as a homolog of an avian retroviral oncogene. It belongs to the family of transcription factors which are characterized by basic region helix-loop-helix/leucine zipper. Along with N-Myc and L-Myc, it forms the MYC proto-oncogene family. It forms a heterodimer with MAX, and this heterodimer binds to the E-boxes/CACGTG sequence motif on DNA. This gene is localized to human chromosome 8q24.
特異性
The antibody detects transfected proteins contanining c-Myc Tag.
免疫原
Synthetic peptide: C-EQKLISEEDL conjugated with KLH.
アプリケーション
Anti-c-Myc Tag antibody produced in rabbit has been used in western blotting.
生物化学的／生理学的作用
v-myc avian myelocytomatosis viral oncogene homolog belongs to MYC family. When overexpressed, these proteins can delay the resolution of DNA lesions and cause DNA double-strand breaks (DSBs) and genome instability. This transcription factor MYC helps in regulating long noncoding RNAs (lncRNAs), which has been implicated in cancer cell proliferation and tumorigenesis. Its overexpression is also associated with various cancers, and in particular B cell lymphomas. Elevated expression of c-MYC inhibits the ability of B cell lymphomas to functionally present antigens/peptides to CD4+ T cells. It is associated with Burkitt lymphoma and a group of diffuse large B-cell lymphoma (DLBCL).
特徴および利点
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
物理的形状
Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol.
免責事項
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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保管分類コード
10 - Combustible liquids
WGK
WGK 1
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
Jan Code
SAB4301136-100UL:
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MYC impairs resolution of site-specific DNA double-strand breaks repair.
Ambrosio S, et al.
Mutation Research. Fundamental and Molecular Mechanisms of Mutagenesis, 774, 6-13 (2015)
Clinicopathologic and prognostic significance of c-MYC copy number gain in lung adenocarcinomas.
Seo A N, et al.
British Journal of Cancer, 110(11), 2688-2688 (2014)
Role of MYC-regulated long noncoding RNAs in cell cycle regulation and tumorigenesis.
Kim T, et al.
Journal of the National Cancer Institute, 107(4), dju505-dju505 (2015)
Expression profiles of MYC protein and MYC gene rearrangement in lymphomas.
Chisholm K M, et al.
American Journal of Surgical Pathology, 39(3), 294-303 (2015)
Sayo Kodama et al.
mBio, 13(5), e0223622-e0223622 (2022-09-27)
Many biotrophic and hemibiotrophic fungal pathogens use appressoria to directly penetrate the host plant surface. In the cucumber anthracnose fungus Colletotrichum orbiculare, differentiation of appressoria requires a proper G1/S cell cycle progression, regulated by the GTPase-activating protein complex CoBub2-CoBfa1 and
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