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由来生物
rabbit
結合体
unconjugated
抗体製品の状態
affinity isolated antibody
抗体製品タイプ
primary antibodies
クローン
polyclonal
形状
buffered aqueous solution
分子量
~88 kDa
化学種の反応性
mouse, human, rat
濃度
1 mg/mL
テクニック
immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:100
indirect immunofluorescence: 1:100-1:200
western blot: 1:500-1:1000
アイソタイプ
IgG
免疫原配列
(P-M-SP-P-R)
NCBIアクセッション番号
UniProtアクセッション番号
輸送温度
wet ice
保管温度
−20°C
ターゲットの翻訳後修飾
phosphorylation (pSer727)
遺伝子情報
human ... STAT3(6774)
詳細
Signal transducer and activator of transcription 3 (STAT3), a constituent of the interleukin-6- (IL-6) activated acute phase response factor (APRF) complex, belongs to the signal transducer and activator of transcription (STAT) family. It is expressed in all types of tissues. The STAT3 gene with 24 exons is mapped to human chromosome 17q21.2.
免疫原
Peptide sequence around phosphorylation site of serine 727 (P-M-S(p)-P-R), according to the protein STAT3.
アプリケーション
Anti-phospho-STAT3 (pSer727) antibody produced in rabbit has been used in immunoblotting (1:1000) and immunofluorescence staining (1:200).
生物化学的／生理学的作用
Signal transducer and activator of transcription 3 (STAT3) protein play a key role in cell growth, apoptosis, metabolism, cellular respiration, and autophagy. It may act as a co-activator of signal transduction by glucocorticoid receptors. STAT3 regulates transcription. It is involved in the development of vertebrates and the regulation of inflammation and immunity. It might participate in airway inflammation, allergy, and asthma. Mutations in the STAT3 gene are associated with immunodeficiency, autoimmunity, and cancer.
特徴および利点
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
ターゲットの説明
Transcription factor that binds to the interleukin-6 (IL-6)-responsive elements identified in the promoters of various acute-phase protein genes. Activated by IL31 through IL31RA.
物理的形状
PBS（0.02％ アジ化ナトリウム、50％ グリセロール含有）
免責事項
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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保管分類コード
10 - Combustible liquids
WGK
WGK 1
引火点(°F)
Not applicable
引火点(℃)
Not applicable
試験成績書（COA）
製品のロット番号・バッチ番号を入力して、試験成績書（COA） を検索できます。ロット番号・バッチ番号は、製品ラベルに「Lot」または「Batch」に続いて記載されています。
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Emily J Hillmer et al.
Cytokine & growth factor reviews, 31, 1-15 (2016-05-18)
The transcriptional regulator STAT3 has key roles in vertebrate development and mature tissue function including control of inflammation and immunity. Mutations in human STAT3 associate with diseases such as immunodeficiency, autoimmunity and cancer. Strikingly, however, either hyperactivation or inactivation of
Fabian Gärtner et al.
Frontiers in immunology, 12, 745132-745132 (2021-12-07)
Thoracic traumas with extra-thoracic injuries result in an immediate, complex host response. The immune response requires tight regulation and can be influenced by additional risk factors such as obesity, which is considered a state of chronic inflammation. Utilizing high-dimensional mass
Aihong Wang et al.
Biology open, 8(9) (2019-09-04)
Human epididymis protein 4 (HE4) is well known to be a predictor of ovarian cancer clinically. HE4 is reported to play crucial roles in ovarian cancer progression and metastasis. The purpose of the present study was to explore its biological
Xiaoping Pan et al.
Life sciences, 214, 124-135 (2018-11-06)
Although the anti-neoplastic effects of physcion are well documented, its specific action in hepatocellular carcinoma (HCC) is not understood. Taken together, physcion is a promising drug candidate for the treatment and prevention of HCC. Cell Counting Kit-8 (CCK-8) assay utilized
Ilaria Marrocco et al.
Cells, 8(9) (2019-09-11)
Prostate cancer (PCa) is a multifactorial disease characterized by the aberrant activity of different regulatory pathways. STAT3 protein mediates some of these pathways and its activation is implicated in the modulation of several metabolic enzymes. A bioinformatic analysis indicated a
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