SAB4200707

Anti-Desmin antibody, Mouse monoclonal

clone DE-U-10, purified from hybridoma cell culture

• 別名: 抗DES抗体
• UNSPSCコード: 12352203
• NACRES: NA.41

特性

• 抗体製品の状態: purified from hybridoma cell culture
• 品質水準: 200
• 抗体製品タイプ: primary antibodies
• クローン: DE-U-10, monoclonal
• フォーム: buffered aqueous solution
• 分子量: antigen ~55 kDa
• 交差性: rat, rabbit, hamster, porcine, goat, bovine, chicken, toad, sheep, mouse, human
• 強化検証: independent; Learn more about Antibody Enhanced Validation
• 濃度: ~1.0 mg/mL
• テクニック: immunoblotting: 0.5-1 μg/mL using whole extract of mouse myoblast C2C12 cells; immunofluorescence: 2-5 μg/mL using mouse myoblast C2C12 cells; immunohistochemistry: 2.5-5 μg/mL using heat-retrieved formalin-fixed, paraffin-embedded Human Appendix; microarray: suitable
• アイソタイプ: IgG1
• UniProtアクセッション番号: P02540
• 輸送温度: dry ice
• 保管温度: −20°C
• ターゲットの翻訳後修飾: unmodified
• 遺伝子情報: human ... DES(1674) ; mouse ... Des(13346) ; rat ... Des(64362)

詳細

詳細

Anti-Desmin antibody, Mouse monoclonal (mouse IgG1 isotype) is derived from the hybridoma DE-U-10 produced by the fusion of mouse myeloma cells and splenocytes from an immunized BALB/C mouse. Desmin, a major intermediate filament protein in skeletal, cardiac and smooth muscle cells. It is predominantly localised to filamentous extrasarcomeric cytoskeleton, which links neighbouring myofibrils and connects the myofibrillar apparatus with the subsarcolemmal cytoskeleton, myonuclei and mitochondria.

免疫原

Desmin purified from pig stomach

アプリケーション

Anti-Desmin antibody, Mouse monoclonal has been used in:

• immunoblotting
• immunofluorescence
• immunohistochemistry
• microarray

生物化学的／生理学的作用

Mutations is the desmin gene (known as desminopathy or DRM) are associated with several human diseases such as atrophy and facial muscle weakness, cardiomyopathy, cardiac arrhythmias and restrictive heart failure and are characterized by intracellular desmin aggregates. Anti-Desmin antibodies can be implemented for cancer research and diagnostics since elevated levels of desmin characterize several types of muscle tissue tumors, such as leiomyomas and rhabdomyosarcomas. The antibody may also be used for meat research measurements.

物理的形状

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

免責事項

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全性情報

• 保管分類コード: 10 - Combustible liquids
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable