SAB4200686

Anti-Collagen, Type VII antibody, Mouse monoclonal

clone LH7.2, purified from hybridoma cell culture

• 別名: Monoclonal Anti-Collagen, Type VII antibody produced in mouse, COL7A1, EBD1, EBDCT, EBR1, alpha 1, collagen, type VII
• UNSPSCコード: 12352203
• NACRES: NA.41

特性

• 由来生物: mouse
• 品質水準: 200
• 抗体製品の状態: purified immunoglobulin
• 抗体製品タイプ: primary antibodies
• クローン: LH7.2, monoclonal
• 形状: buffered aqueous solution
• 化学種の反応性: human
• 包装: antibody small pack of 25 μL
• 濃度: ~1 mg/mL
• テクニック: immunoblotting: suitable; immunohistochemistry: 1.5-3 μg/mL using frozen human tonsil sections
• アイソタイプ: IgG1
• 輸送温度: dry ice
• 保管温度: −20°C
• ターゲットの翻訳後修飾: unmodified
• 遺伝子情報: human ... COL7A1(1294)

詳細

詳細

Monoclonal Anti-Collagen Type VII (mouse IgG1 isotype) is derived from the hybridoma LH7.2 produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mice. Collagen Type VII (known also as Col7), which belongs to the collagen superfamily, is a major extracellular matrix component of the anchoring fibrils in lamina densa. COL7A1 (collagen type VII alpha 1 chain) gene codes for type VII collagen. It is located on human chromosome 3p. It is expressed by keratinocytes and fibroblasts. COL7A1 is the important component the anchoring fibrils.

免疫原

insoluble fractions prepared from neonatal foreskin epidermal cells

アプリケーション

Monoclonal Anti-Collagen, Type VII antibody produced in mouse has been used in:

• enzyme-linked immunosorbent assay (ELISA)
• immunoblotting
• immunohistochemistry
• immunofluorescence

生物化学的／生理学的作用

Collagen type VII is very essential for adhesive connection between the dermis and the epidermal basement membrane zone (BMZ). Mutations in collagen type VII cause dystrophic forms of epidermolysis bullosa (including recessive dystrophic epidermolysis bullosa (RDEB)), which manifest as skin fragility and malformed enamel.

物理的形状

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

免責事項

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全性情報

• 保管分類コード: 12 - Non Combustible Liquids
• WGK: nwg
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable