SAB4200565

Monoclonal Anti-ZFP36/TTP antibody produced in mouse

clone TTP6, tissue culture supernatant

• 別名: 抗G0S24抗体, 抗NUP475抗体, 抗RNF162A抗体
• UNSPSCコード: 12352203
• NACRES: NA.41

特性

• 由来生物: mouse
• 品質水準: 200
• 結合体: unconjugated
• 抗体製品の状態: tissue culture supernatant
• 抗体製品タイプ: primary antibodies
• クローン: TTP6, monoclonal
• 形状: buffered aqueous solution
• 分子量: antigen ~45 kDa
• 化学種の反応性: mouse, bovine, rat, dog, human, monkey
• テクニック: western blot: 1:4,000-1:8,000 using extracts of HepG2 cells.
• UniProtアクセッション番号: P26651
• 輸送温度: dry ice
• 保管温度: −20°C
• ターゲットの翻訳後修飾: unmodified
• 遺伝子情報: human ... ZFP36(7538)

詳細

詳細

Monoclonal Anti-ZFP36/TTP (mouse IgM isotype) is derived from the hybridoma TTP6 produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mice immunized with a peptide corresponding to an internal sequence of human ZFP36/TTP, conjugated keyhole limpet hemocyanin (KLH). ZFP36 (also known as tristetraprolin or TTP) is a RNA-binding protein. It belongs to the RNA-binding zinc-finger protein family. TTP consists of a cysteine-cysteine-cysteine-histidine (CCCH) zinc finger motif and uridine-rich elements (AREs) in the 3′ untranslated region (3′ UTR) of target mRNA. This gene is located on human chromosome 19q13.1.

免疫原

a peptide corresponding to an internal sequence of human ZFP36/TTP conjugated KLH.

アプリケーション

Monoclonal Anti-ZFP36/TTP antibody has been used in immunoblotting.

生物化学的／生理学的作用

ZFP36 (also known as tristetraprolin or TTP) participates in controlling the expression of AU-rich element (ARE) -containing mRNAs. It participates in accelerating mRNA decay. ZFP36 was found to limit the expression of a number of critical genes frequently overexpressed in inflammation and cancer. It also plays a major role in differentiation, reprogramming, metabolism, proliferation, pluripotency, tumorigenesis and immunity.

物理的形状

Solution in Dulbecco′s Modified Eagle′s Medium with 10% fetal calf serum and 15 mM sodium azide.

免責事項

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全性情報

• 保管分類コード: 10 - Combustible liquids
• WGK: WGK 3