おすすめの製品
由来生物
rabbit
結合体
unconjugated
抗体製品の状態
IgG fraction of antiserum
抗体製品タイプ
primary antibodies
クローン
polyclonal
形状
buffered aqueous solution
化学種の反応性
human
テクニック
immunocytochemistry: suitable
immunofluorescence: suitable
immunoprecipitation (IP): suitable
indirect ELISA: suitable
western blot: suitable
NCBIアクセッション番号
UniProtアクセッション番号
輸送温度
dry ice
保管温度
−20°C
ターゲットの翻訳後修飾
unmodified
遺伝子情報
human ... BAX(581)
詳細
BCL2 associated X, apoptosis regulator (BAX) is a proapoptotic protein of the B-cell lymphoma 2 (BCL2) protein family. The gene encoding it is localized on human chromosome 19q13.33.
免疫原
Bax antibody was raised against a peptide corresponding to 16 amino acids near the amino-terminus of human Bax.
アプリケーション
Anti-Bax antibody produced in rabbit has been used in Western blotting.
生物化学的／生理学的作用
BCL2 associated X, apoptosis regulator (BAX) forms a heterodimer with B-cell lymphoma 2 (BCL2) and functions as an apoptotic activator. BAX interacts with and increases the opening of the mitochondrial voltage-dependent anion channel (VDAC), which leads to the loss in the mitochondrial membrane potential and the release of cytochrome c. The expression of BAX gene is regulated by the tumor suppressor p53 and BAX has been shown to be involved in p53-mediated apoptosis.
特徴および利点
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
関連事項
The action of this antibody can be blocked using blocking peptide SBP3500343.
物理的形状
PBS（0.02％ アジ化ナトリウム含有）
免責事項
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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保管分類コード
10 - Combustible liquids
WGK
WGK 2
引火点(°F)
Not applicable
引火点(℃)
Not applicable
試験成績書（COA）
製品のロット番号・バッチ番号を入力して、試験成績書（COA） を検索できます。ロット番号・バッチ番号は、製品ラベルに「Lot」または「Batch」に続いて記載されています。
Bcl-2 family proteins and cancer
K W Yip
Oncogene (2008)
The role of Bcl-2 and its pro-survival relatives in tumourigenesis and cancer therapy
P N Kelly
Cell Death and Differentiation (2011)
HspB8 mediates neuroprotection against OGD/R in N2A cells through the phosphoinositide 3-kinase/Akt pathway
Zhiping Hu
Brain Research (2016)
Wnt signal transduction pathway and apoptosis: a review
Nives Pecina-Slaus
Cancer Cell International (2010)
Voltage-Dependent Anion Channel 1(VDAC1) Participates the Apoptosis of the Mitochondrial Dysfunction in Desminopathy
Huanyin Li
PLoS ONE (2016)
ライフサイエンス、有機合成、材料科学、クロマトグラフィー、分析など、あらゆる分野の研究に経験のあるメンバーがおります。.
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