RAB0441

Phospho-Stat1 (pSer⁷²⁷) and pan-Stat1 ELISA Kit

for detection of phospho-stat1 (pSer⁷²⁷) and pan-stat1 in human or mouse cell and tissue lysates

• UNSPSCコード: 41116158
• NACRES: NA.32

特性

• 化学種の反応性: mouse, human
• テクニック: ELISA: suitable; capture ELISA: suitable
• 輸送温度: wet ice
• 保管温度: −20°C
• 遺伝子情報: human ... STAT1(6772) ; mouse ... STAT1(20846)

詳細

詳細

The Phospho-Stat1 (pSer⁷²⁷) ELISA (Enzyme-Linked Immunosorbent Assay) kit is a very rapid, convenient and sensitive assay kit that can monitor the activation or function of important biological pathways in cell lysates.

免疫原

Stat1 (pTyr⁷²⁷) synthetic phosphopeptide, Recombinant Human STAT1

アプリケーション

For research use only. Not for use in diagnostic procedures.
Please refer to the attached General ELISA KIT Procedure (sandwich, competitive & Indirect ELISA)

生物化学的／生理学的作用

Signal transducer and activator of transcription 1 (STAT1) undergoes phosphorylation on serine-727. This Phospho-Stat1 regulates pro- and anti-apoptotic genes following several stress-induced responses. STAT-1 interacts with p53 and promotes p53-mediated transcriptional gene activity and apoptosis. STAT-1 is an essential factor of stress-induced and DNA damage-induced checkpoint pathways and thus, acts as a tumour suppressor. STAT-1 functions as a pro-apoptotic factor in cardiac myocytes, brain or liver exposed to ischaemia–reperfusion injury. Thus, inhibition of STAT-1-activated pathway by epigallocatechin-3-gallate (EGCG), can be considered as a potential therapeutic method against ischaemic tissue injury. Repression of STAT-1 expression by human papillomavirus (HPV) oncoproteins E6 and E7 at transcription level is essential for genome amplification and maintenance of episomes, which is suggested to have a crucial role in viral pathogenesis.

安全性情報

• ピクトグラム: GHS05,GHS07
• シグナルワード: Warning
• 危険有害性情報: H290,H335
• 危険有害性の分類: Met. Corr. 1 - STOT SE 3
• ターゲットの組織: Respiratory system
• 保管分類コード: 8A - Combustible corrosive hazardous materials