R8526

RO-52 (SSA) human

recombinant, expressed in E. coli, liquid

• 別名: Anti-RO-52 antibody
• MDL番号: MFCD03458409
• UNSPSCコード: 12352202
• NACRES: NA.56

特性

• 由来生物: human
• 品質水準: 200
• リコンビナント: expressed in E. coli
• フォーム: liquid
• 分子量: 52 kDa by SDS-PAGE
• テクニック: ELISA: suitable
• UniProtアクセッション番号: P19474
• 保管温度: −70°C
• 遺伝子情報: human ... TRIM21(6737)

詳細

詳細

Research area: Cell Signaling
RO-52 (SSA), also called as tripartite motif-containing protein 21 (TRIM21) is a 52 kDa, ubiquitin E3 ligase. It has a N-terminal RING finger domain (Really Interesting New Gene), crucial for ubiquitination functionality. RO-52 (SSA) gene is mapped to human chromosome 11p5.5.

アプリケーション

RO-52 (SSA) human has been used:

• as a component of the autoantigen array
• to immobilise protein on the self-assembly monolayer
• in enzyme-linked immunosorbent assays (ELISAs)

生物化学的／生理学的作用

RO-52 (SSA) is capable of autoubiquitination and uniquitylates p62 protein and regulates redox homeostasis.Patients with Sjogren′s syndrome display elevated levels of anti-Ro/SSA antibodies. RO-52 levels in peripheral blood mononuclear cells (PBMC) contributes to pathogenesis of systemic lupus erythematosus (SLE), systemic autoimmune rheumatic diseases (SARDs), interstitial lung disease (ILD) and connective tissue diseases (CTD). RO-52 is considered as potential target for treating SLE.

Used for the detection and quantification of antibodies to RNPs in rheumatic diseases.

物理的形状

solution contains 20 mM phosphate buffer, 500 mM NaCl, 2M - 3M urea, pH 6.

安全性情報

• 保管分類コード: 10 - Combustible liquids
• WGK: WGK 2
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable