PZ0115

CP-31398 二塩酸塩 水和物

≥98% (HPLC)

• 別名: N'-[2-[2-(4-メトキシフェニル)エテニル]-4-キナゾリニル]-N,N-ジメチル-1,3-プロパンジアミン 二塩酸塩 水和物
• 実験式（ヒル表記法）: C₂₂H₂₆N₄O·2HCl · xH₂O
• 分子量: 435.39 (anhydrous basis)
• MDL番号: MFCD17215956
• UNSPSCコード: 12352200
• PubChem Substance ID: 329823707
• NACRES: NA.77

特性

• 品質水準: 100
• アッセイ: ≥98% (HPLC)
• 保管条件: desiccated
• 色: yellow
• 溶解性: H₂O: ≥20 mg/mL
• 保管温度: 2-8°C
• SMILES記法: O.Cl.Cl.COc1ccc(cc1)\C=C\c2nc(NCCCN(C)C)c3ccccc3n2
• InChI: 1S/C22H26N4O.2ClH.H2O/c1-26(2)16-6-15-23-22-19-7-4-5-8-20(19)24-21(25-22)14-11-17-9-12-18(27-3)13-10-17;;;/h4-5,7-14H,6,15-16H2,1-3H3,(H,23,24,25);2*1H;1H2/b14-11+;;;
• InChI Key: JXIVIAMOMIONKY-UWCBQFGESA-N
• 遺伝子情報: human ... TP53(7157) ; mouse ... TP53(22059) ; rat ... TP53(24842)

詳細

アプリケーション

CP-31398 dihydrochloride hydrate has been used as a p53 stabilizer:

• to evaluate its effects on the upregulation of miRNA in human neuroblastoma cells
• to study its effects on arsenic trioxide (ATO) stabilization of p53 folding
• to study its effects on regulation of miR-34 in PC12 cells

生物化学的／生理学的作用

CP-31398 is a styryl quinazoline that functions in preserving the activity of p53 as a tumor suppressor and transcription factor. The DNA-binding activity and apoptosis functionality of the p53 are restored by CP-31398. CP-31398 exhibits therapeutic effects against liver, skin, pancreatic, and colon cancers.

CP-31398二塩酸塩水和物はp53の安定化物質であり、アポトーシス誘導物質です。

特徴および利点

This compound is a featured product for Apoptosis research. Click here to discover more featured Apoptosis products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

安全性情報

• ピクトグラム: GHS07
• シグナルワード: Warning
• 危険有害性情報: H302,H315,H319,H413
• 注意書き: P264 - P273 - P280 - P301 + P312 - P302 + P352 - P305 + P351 + P338
• 危険有害性の分類: Acute Tox. 4 Oral - Aquatic Chronic 4 - Eye Irrit. 2 - Skin Irrit. 2
• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable