おすすめの製品
由来生物
mouse
品質水準
結合体
unconjugated
抗体製品の状態
purified immunoglobulin
抗体製品タイプ
primary antibodies
クローン
PRMT1-171, monoclonal
フォーム
buffered aqueous solution
分子量
antigen ~42 kDa
交差性
mouse, chicken, bovine, human, canine, hamster, monkey, rat
濃度
~2 mg/mL
テクニック
immunoprecipitation (IP): suitable
indirect ELISA: suitable
western blot: 2 μg/mL using whole cell extract of 293T cells
アイソタイプ
IgG1
UniProtアクセッション番号
輸送温度
dry ice
保管温度
−20°C
ターゲットの翻訳後修飾
unmodified
遺伝子情報
human ... PRMT1(3276)
詳細
Protein arginine methyltransferase 1 (PRMT1) gene is localized on human chromosome 19q13.33. It is part of the type I PRMT family.
特異性
Does not cross-react with PRMT2, 3, 4, and 5.
免疫原
full length PRMT1. Does not cross-react with PRMT2, 3, 4, and 5.
アプリケーション
Anti-PRMT1 antibody, Mouse monoclonal has been used for Immunofluorescence and Western Blotting.
生物化学的／生理学的作用
Protein arginine methyltransferase 1 (PRMT1) is crucial for the formation of asymmetric dimethylarginine. It can methylate Twist-1, a transcription factor. The protein also methylates histones and thus modulates transcription and protein activity. PRMT1 is involved in epithelial-mesenchymal transition and may have a role in cancer.
物理的形状
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
保管および安定性
For continuous use, store at 2-8 C for up to one month. For prolonged storage, freeze in working aliquots at 20 C. Repeated freezing and thawing, or storage in frost-free freezers, is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilutions should be discarded if not used within 12 hours.
免責事項
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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関連製品
製品番号
詳細
価格
保管分類コード
12 - Non Combustible Liquids
WGK
WGK 2
引火点(°F)
Not applicable
引火点(℃)
Not applicable
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
Jan Code
P1620-200UL:
P1620-VAR:
P1620-BULK:
最新バージョンのいずれかを選択してください：
PRMT1-mediated arginine methylation controls ATXN2L localization.
Kaehler C, et al.
Experimental Cell Research, 334(1), 114-125 (2015)
Common fusion transcripts identified in colorectal cancer cell lines by high-throughput RNA sequencing.
Nome T, et al.
Translational Oncology, 6(5), 546-IN5-546-IN5 (2013)
PRMT1 Is a Novel Regulator of Epithelial-Mesenchymal-Transition in Non-small Cell Lung Cancer.
Avasarala S, et al.
The Journal of Biological Chemistry, 290(21), 13479-13489 (2015)
PRMT1 promotes glucose toxicity-induced β cell dysfunction by regulating the nucleo-cytoplasmic trafficking of PDX-1 in a FOXO1-dependent manner in INS-1 cells.
Lv L, et al.
Endocrine, 49(3), 669-682 (2015)
Vladimir Ljubicic et al.
American journal of physiology. Cell physiology, 302(1), C110-C121 (2011-09-24)
In the present study, we evaluated how a pharmacologically induced phenotype shift in dystrophic skeletal muscle would affect subsequent intracellular signaling in response to a complementary, adaptive physiological stimulus. mdx mice were treated with the AMP-activated protein kinase (AMPK) activator
ライフサイエンス、有機合成、材料科学、クロマトグラフィー、分析など、あらゆる分野の研究に経験のあるメンバーがおります。.
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