P1374

抗Pro-BDNF ウサギ宿主抗体

affinity isolated antibody, lyophilized powder

• 別名: 抗脳由来神経栄養因子前駆体抗体
• MDL番号: MFCD08705507
• UNSPSCコード: 51111800
• NACRES: NA.41

特性

• 由来生物: rabbit
• 品質水準: 200
• 結合体: unconjugated
• 抗体製品の状態: affinity isolated antibody
• 抗体製品タイプ: primary antibodies
• クローン: polyclonal
• フォーム: lyophilized powder
• 化学種の反応性: mouse, human, rat
• テクニック: western blot: 1:200 using rat glioma C6 and human neuroblastoma SH-SY5Y cell lines; western blot: 1:400 using recombinant mouse proBDNF
• UniProtアクセッション番号: P23560
• 輸送温度: wet ice
• 保管温度: −20°C
• ターゲットの翻訳後修飾: unmodified
• 遺伝子情報: human ... BDNF(627) ; mouse ... Bdnf(12064) ; rat ... Bdnf(24225)

詳細

詳細

pro-NGF、pro-NT-3、成熟BDNFとは交差反応しません。

The brain derived neurotrophic factor (BDNF) gene is mapped to human chromosome 11p14.1. The gene encodes a precursor protein, proBDNF. Mature BDNF (mBDNF) is synthesized by post-translational cleavage of proBDNF. Does not cross react with pro-NGF, pro-NT-3, or mature BDNF.

免疫原

ヒトPro-BDNFのアミノ酸72~88に対応するペプチド。この配列は、マウス・ラットで16/17残基一致します。

アプリケーション

Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Immunofluorescence (1 paper)

生物化学的／生理学的作用

Brain derived neurotrophic factor (BDNF) belongs to a family of secreted proteins called neurotrophins. Neurotrophins are synthesized as preproneurotrophin precursors and further processed to proneurotrophins and subsequently to neurotrophins. BDNF is expressed in the developing and the mature brain. The influence of BDNF is mediated by its binding to TrkB receptor and sometimes the receptor p75^NTR. The downstream pathways promoted by BDNF include PI3K, MAPK and JAK/STAT. The most important role of BDNF is the regulation of synaptic transmission and plasticity, protein synthesis and phosphorylation of local proteins.

物理的形状

凍結乾燥品 (PBS, pH 7.4, 1%BSA, 0.025%アジ化ナトリウム含有)。

免責事項

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable