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由来生物
rabbit
品質水準
結合体
unconjugated
抗体製品の状態
affinity isolated antibody
抗体製品タイプ
primary antibodies
クローン
polyclonal
フォーム
buffered aqueous glycerol solution
分子量
antigen 80 kDa
化学種の反応性
rat, human, mouse
テクニック
western blot: 1:1000
UniProtアクセッション番号
輸送温度
dry ice
保管温度
−20°C
遺伝子情報
human ... MARCKS(4082)
mouse ... Marcks(17118)
rat ... Marcks(25603)
詳細
The proteins of myristoylated alanine-rich C kinase substrate (MARCKS) family are identified as the ubiquitous substrates of Protein Kinase C (PKC). There are two identified members of MARCKS family, a 32 kDa ubiquitously expressed protein and a 20 kDa protein that is expressed in brain, macrophages and reproductive tissues. MARCKS proteins have vital role to play in the development of brain, cellular migration and adhesion, phagocytosis, neurosecretion and postnatal survival. MARCKS is also a key regulator in the mucin granule release and thereby secretion of mucus in airway. The phosphorylation domain of MARCKS protein contains the serine residues (serine 152, 156 and 163) that are activated by PKC. Besides PKC, MARCKS is also a target for calcium-calmodulin (CaM) and is reported as the potential protein that mediates a crosstalk between CaM and PKC. MARCKS participates in regulation of cytoskeleton by binding with actin and cell membrane
Anti-phospho-MARCKS (pSer152/156) specifically recognizes MARCKS (80 kDa) phosphorylated at serine 152/156.
Anti-phospho-MARCKS (pSer152/156) specifically recognizes MARCKS (80 kDa) phosphorylated at serine 152/156.
免疫原
ラットMARCKSのセリン152/156がリン酸化された領域に由来する合成リン酸化ペプチド。
アプリケーション
A working dilution of 1:1000 is recommended for detection of MARCKS, phosphorylated at Ser152/156, by immunoblotting in rat hippocampal tissue homogenates.
物理的形状
10mM HEPES溶液 (pH 7.5, 150mM NaCl, 100μg/mL BSA, 50%グリセロ-ル含有)。
免責事項
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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保管分類コード
10 - Combustible liquids
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
Jan Code
P0370-100UL:
P0370-BULK:
P0370-VAR:
P0370-100UL-PW:
The MARCKS brothers: a family of protein kinase C substrates.
A Aderem
Cell, 71(5), 713-716 (1992-11-27)
Duncan F Rogers
Respiratory care, 52(9), 1134-1146 (2007-08-25)
Mucus secretion is the first-line defense against the barrage of irritants that inhalation of approximately 500 L of air an hour brings into the lungs. The inhaled soot, dust, microbes, and gases can all damage the airway epithelium. Consequently, mucus
Anna Arbuzova et al.
The Biochemical journal, 362(Pt 1), 1-12 (2002-02-07)
The proteins of the MARCKS (myristoylated alanine-rich C kinase substrate) family were first identified as prominent substrates of protein kinase C (PKC). Since then, these proteins have been implicated in the regulation of brain development and postnatal survival, cellular migration
R H Palmer et al.
FEBS letters, 378(3), 281-285 (1996-01-15)
The 80kDa Myristolated Alanine-Rich C-Kinase Substrate (MARCKS) is a major in vivo substrate of protein kinase C (PKC). Here we report that MARCKS is a major substrate for the lipid-activated PKC-related kinase (PRK1) in cell extracts. Furthermore, PRK1 is shown
Y Li et al.
The Journal of biological chemistry, 276(44), 40982-40990 (2001-09-05)
Hypersecretion of airway mucin characterizes numerous respiratory diseases. Although diverse pathological stimuli can provoke exocytotic release of mucin from secretory cells of the airway epithelium, mechanisms involved remain obscure. This report describes a new paradigm for the intracellular signaling mechanism
ライフサイエンス、有機合成、材料科学、クロマトグラフィー、分析など、あらゆる分野の研究に経験のあるメンバーがおります。.
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