MSST0035

SILu^™Prot CCL2 C-C motif chemokine 2 human

SIL MS Protein Standard, ¹³C and ¹⁵N-labeled

• 別名: 単球化学誘引タンパク質1
• UNSPSCコード: 23201100
• NACRES: NA.12

特性

• 由来生物: human
• 品質水準: 200
• アッセイ: ≥98% (SDS-PAGE)
• 形状: lyophilized powder
• 有効性: ≥98% Heavy amino acids incorporation efficiency by MS
• テクニック: mass spectrometry (MS): suitable
• 適合性: suitable for mass spectrometry (standard)
• UniProtアクセッション番号: P13500
• 保管温度: −20°C
• 遺伝子情報: human ... CCL2(6347)

詳細

詳細

CCL2, the most thoroughly characterized CC chemokine, is a monocyte-specific chemoattractant that was demonstrated to attract T lymphocytes and NK cells, but not neutrophils. Enhanced expression of CCL2 was demonstrated in a variety of pathologic conditions, associated with inflammation and mononuclear cell infiltration. Extensive experimental evidence suggests that CCL2 is highly expressed in atherosclerotic plaques. In a recent study, CCL2 was shown to have value as a biomarker for risk stratification in both the initial and the chronic phases after an acute coronary syndromes (ACS). In contrast to CRP, CCL2 levels may be an indicator of long-term cardiovascular risk rather than a marker of acute prognosis. In urine, CCL2 levels were directly associated to Systemic Lupus Erythematosus disease activity, making it a non-invasive biomarker (avoiding blood sampling or tissue biopsies).

免疫原

QPDAINAPVTCCYNFTNRKISVQRLASYRRITSSKCPKEAVIFKTIVAKEICADPKQKWVQDSMDHLDKQTQTPKTDYKDDDDKGHHHHHHHHGGQ

生物化学的／生理学的作用

SILu^™Prot CCL2 is a recombinant, stable isotope-labeled human CCL2 which incorporates [¹³C₆, ¹⁵N₄]-Arginine and [¹³C₆, ¹⁵N₂]-Lysine. Expressed in human 293 cells, it is designed to be used as an internal standard for bioanalysis of CCL2 in mass-spectrometry. SILu Prot CCL2 is a homodimer consisting of 96 amino acids (including C-terminal polyhistidine and FLAG^® tags), with a calculated molecular mass of 11 kDa.

物理的形状

Lyophilized from a solution of phosphate buffered saline.

法的情報

This product is licensed under U.S. Patent No. 7,396,688 and foreign counterparts from E. I. du Pont de Nemours and Company. The purchase of this product conveys to the buyer the nontransferable right to use the purchased amount of the product for research and development only, including services for a third party for consideration. The buyer cannot sell or otherwise transfer this product, its components or materials made using this product or its components to a third party. Information about licenses for excluded uses is available from: E. I. du Pont de Nemours and Company; Attn: Associate Director, Commercial Development; DuPont Experimental Station E268; 200 Powdermill Rd.; Wilmington, DE 19803; 1-877-881-9787 (voice), 1-302-695-1437 (fax), licensing@dupont.com.

FLAG is a registered trademark of Merck KGaA, Darmstadt, Germany

SILu is a trademark of Sigma-Aldrich Co. LLC

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 2
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable