M7945

Mephetyl tetrazole

≥98% (HPLC), oil

• 別名: 1-[2-(4-Methoxyphenyl)ethyl]-5-(1-p-tolylcyclopropyl)-1H-tetrazole
• 実験式（ヒル表記法）: C₂₀H₂₂N₄O
• CAS番号: 916923-10-9
• 分子量: 334.41
• MDL番号: MFCD11045297
• UNSPSCコード: 12352200
• PubChem Substance ID: 329818044
• NACRES: NA.77

特性

• 品質水準: 100
• アッセイ: ≥98% (HPLC)
• 形状: oil
• 色: pale yellow
• 溶解性: DMSO: >5 mg/mL
• 保管温度: 2-8°C
• SMILES記法: COc1ccc(CCn2nnnc2C3(CC3)c4ccc(C)cc4)cc1
• InChI: 1S/C20H22N4O/c1-15-3-7-17(8-4-15)20(12-13-20)19-21-22-23-24(19)14-11-16-5-9-18(25-2)10-6-16/h3-10H,11-14H2,1-2H3
• InChI Key: VREPWWBWXVLSEF-UHFFFAOYSA-N

詳細

生物化学的／生理学的作用

Mephetyl tetrazole is a potent and selective Kv1.5 potassium channel blocker. IC₅₀ = 330 nM; shows selective atrial prolongation (40%) of effective refractory period (ERP), but no effect on ventricular ERP Kv1.5 channel is a molecular target for the treatment of atrial fibrillation.

特徴および利点

This compound is featured on the Potassium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable
• 個人用保護具 (PPE): Eyeshields, Gloves, type N95 (US)