M2694

抗Munc-18-1抗体 ウサギ宿主抗体

IgG fraction of antiserum, buffered aqueous solution

• 別名: 抗Munc-18α抗体, 抗STXBP1抗体, 抗rb-Sec-1抗体, 抗シンタキシン結合タンパク質1抗体
• MDL番号: MFCD07370408
• UNSPSCコード: 12352203
• NACRES: NA.41

特性

• 由来生物: rabbit
• 品質水準: 200
• 結合体: unconjugated
• 抗体製品の状態: IgG fraction of antiserum
• 抗体製品タイプ: primary antibodies
• クローン: polyclonal
• フォーム: buffered aqueous solution
• 分子量: antigen 67 kDa
• 化学種の反応性: mouse, rat
• テクニック: indirect immunofluorescence: 1:250-1:500 using mouse fibroblast NIH3T3 cell line; microarray: suitable; western blot: 1:2,000-1:4,000 using rat brain extract (S1 fraction) and PC12 whole cell extract.
• UniProtアクセッション番号: O08599
• 輸送温度: dry ice
• 保管温度: −20°C
• ターゲットの翻訳後修飾: unmodified
• 遺伝子情報: human ... STXBP1(6812) ; mouse ... Stxbp1(20910) ; rat ... Stxbp1(25558)

詳細

詳細

Munc-18-1 (67 kDa) is an abundant neuronal protein that tightly binds to the synaptic fusion protein syntaxin. It is primarily expressed in neuronal tissues. Both Munc-18-1 and 2 isoforms bind tightly to syntaxins 1A, 2, and 3.

免疫原

ラットMunc-18-1のC末端に位置するアミノ酸577-594に相当する合成ペプチドのKLH結合体。この配列は、マウス, ニワトリ, ウシ, ヒトMunc-18-1で一致しています。Munc-18-2およびMunc-18-3アイソフォ-ムとのホモロジ-はありません。

アプリケーション

Anti-Munc-18-1 antibody produced in rabbit has been used in immunoblotting and immunofluorescence.

生物化学的／生理学的作用

Munc-18-1 functions in synaptic vesicle exocytosis. It modulates neurotransmission by associating with syntaxin 1. Munc-18-1 binds to both syntaxin 1A and 1B isoforms, inhibiting the binding of t-soluble N-ethylmaleimide-sensitive factor-attached protein receptor (SNARE) synaptobrevin/vesicle-associated membrane protein (VAMP) and SNAP25 to syntaxin 1 and preventing SNARE assembly. Munc-18 is required for neurotransmitter secretion from synaptic vesicles throughout development and has been implicated in axonal branching in hippocampal neurons.

物理的形状

0.01M PBS溶液 (pH 7.4, 15mMアジ化ナトリウム含有)。

免責事項

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全性情報

• 保管分類コード: 10 - Combustible liquids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable