K0265

Anti-Potassium Channel K_2P4.1 (TRAAK) ウサギ宿主抗体

affinity isolated antibody, lyophilized powder

• 別名: Anti-KCNK4, Anti-TWIK-related arachidonic acid-stimulated K⁺ channel
• MDL番号: MFCD09753858
• UNSPSCコード: 12352203
• NACRES: NA.41
• 結合体: unconjugated
• application: IHC; WB
• クローン: polyclonal
• 化学種の反応性: human, rat
• citations: 2
• テクニック: immunohistochemistry: suitable; western blot: 1:200 using HEK-K_2P4.1 transfected cells or rat cerebellum lysate

特性

• 由来生物: rabbit
• 品質水準: 200
• 結合体: unconjugated
• 抗体製品の状態: affinity isolated antibody
• 抗体製品タイプ: primary antibodies
• クローン: polyclonal
• フォーム: lyophilized powder
• 化学種の反応性: human, rat
• テクニック: immunohistochemistry: suitable; western blot: 1:200 using HEK-K_2P4.1 transfected cells or rat cerebellum lysate
• UniProtアクセッション番号: Q9NYG8
• 保管温度: −20°C
• ターゲットの翻訳後修飾: unmodified
• 遺伝子情報: human ... KCNK4(50801) ; rat ... Kcnk4(116489)

詳細

詳細

The gene K2P4.1, also referred to as KCNK4 (potassium two pore domain channel subfamily K member 4), encodes a protein belonging to the subfamily of K2P (two pore domain K⁺ channel) channels called TRAAK (TWIK-related arachidonic acid-stimulated K⁺ channel). The TRAAK channels are expressed selectively in the nervous system. TRAAK channel contains two protomers, each with two distinct pore domains forming a two-fold symmetric potassium channel.

特異性

The K_2P4.1 antibody is directed against a highly conserved epitope in the intraracellular C-terminal region of the human K_2P4.1 channel.

免疫原

peptide NLAFIDESSDTQSERGC, corresponding to amino acid residues 343-359 of human K_2P4.1.

生物化学的／生理学的作用

The gene KCNK4 (potassium two pore domain channel subfamily K member 4) encodes a potassium channel that is mechanosensitive and is regulated by polyunsaturated fatty acids and temperature. The structure and chemical composition of the lipid bilayer has a profound effect on the functioning of this K⁺ channel. It is found to regulate the noxious input threshold in dorsal root ganglia neurons.

物理的形状

Lyophilized powder from phosphate buffered saline, pH 7.4, containing 1% BSA and 0.025% sodium azide.

再構成

Reconstitute the lyophilized vial with 50 μL or 200 μL deionized water, depending on package size. Further dilutions should be made using a carrier protein, such as BSA (1-3%).

免責事項

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全性情報

• 保管分類コード: 10 - Combustible liquids
• WGK: nwg
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable