I1286

Icariin

≥94% (HPLC)

• 別名: 4′-O-methyl-8-γ,γ-dimethylallylkaempferol-3-rhamnoside-7-glucoside
• 実験式（ヒル表記法）: C₃₃H₄₀O₁₅
• CAS番号: 489-32-7
• 分子量: 676.66
• MDL番号: MFCD00210516
• UNSPSCコード: 12352205
• PubChem Substance ID: 329815347
• NACRES: NA.25

特性

• アッセイ: ≥94% (HPLC)
• 色: light yellow to yellow
• 溶解性: DMSO: 50 mg/mL, clear, colorless to dark yellow
• アプリケーション: metabolomics; vitamins, nutraceuticals, and natural products
• 保管温度: room temp
• SMILES記法: COc1ccc(cc1)C2=C(O[C@@H]3O[C@@H](C)[C@H](O)[C@@H](O)[C@H]3O)C(=O)c4c(O)cc(O[C@@H]5O[C@H](CO)[C@@H](O)[C@H](O)[C@H]5O)c(C\C=C(\C)C)c4O2
• InChI: 1S/C33H40O15/c1-13(2)5-10-17-19(45-33-28(42)26(40)23(37)20(12-34)46-33)11-18(35)21-24(38)31(48-32-27(41)25(39)22(36)14(3)44-32)29(47-30(17)21)15-6-8-16(43-4)9-7-15/h5-9,11,14,20,22-23,25-28,32-37,39-42H,10,12H2,1-4H3/t14-,20+,22-,23+,25+,26-,27+,28+,32-,33+/m0/s1
• InChI Key: TZJALUIVHRYQQB-XLRXWWTNSA-N

詳細

詳細

Icariin is a prenylated flavonol and the major bioactive compound found in Epimedium herb.

アプリケーション

Icariin has been used:

• in the preparation of topical treatment to determine its effects on the improvement of cutaneous wound healing in rats
• to test its analgesic effects on lower back pain (LBP) in rats
• as a potential treatment in osteoporosis condition in rats
• to study its effects on palmitate (PA)-induced insulin resistance in skeletal muscle C2C12 myotubes
• as a neuroprotective agent to study its effects on amyloid-β (Aβ)-induced neuronal insulin resistance in human neuroblastoma SK-N-MC cells

生物化学的／生理学的作用

Flavonoid glucoside derived from the the Epimedium plant genus. This pharmacologically active constituent or its derivatives have been shown to enhance bone formation, modulate multidrug resistance, enhance neuronal viability, stimulate angiogenesis, and exhibit antioxidant activity.

Icariin is a potent neuroprotective agent in neurodegenerative disorders and other disorders affecting the nervous system. It elicits anti-aging properties in unfertilized oocytes against age-related damage. Icariin exerts anti-inflammatory and antifibrotic properties aiding protection in chronic kidney disease (CKD)-associated renal fibrosis in mouse model. It also serves as an excellent antidiabetic and anti-atherosclerotic agent. Icariin is an excellent anti-cancer agent.

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable