HPA025061

Anti-CDK11A antibody produced in rabbit

Prestige Antibodies^® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution

• 別名: Anti-CDC2L2, Anti-CDK11, Anti-Cell division cycle 2-like protein kinase 2, Anti-Galactosyltransferase-associated protein kinase p58/GTA, Anti-PITSLRE serine/threonine-protein kinase CDC2L2
• UNSPSCコード: 12352203
• Human Protein Atlas Number: HPA025061
• NACRES: NA.41

特性

• 由来生物: rabbit
• 品質水準: 100
• 結合体: unconjugated
• 抗体製品の状態: affinity isolated antibody
• 抗体製品タイプ: primary antibodies
• クローン: polyclonal
• 製品種目: Prestige Antibodies^® Powered by Atlas Antibodies
• フォーム: buffered aqueous glycerol solution
• 交差性: human
• テクニック: immunohistochemistry: 1:50- 1:200
• 免疫原配列: YRREDSMEDRGEEDDSLAIKPPQQMSWKEKVHHRKDEKRKEKCRHHSHSAEGGKHARVKEREHERRKRHREEQDKARREWERQKRREMAREHSRRERDRLE
• 輸送温度: wet ice
• 保管温度: −20°C
• ターゲットの翻訳後修飾: unmodified
• 遺伝子情報: human ... CDK11A(728642)

詳細

詳細

The gene CDK11A (cyclin dependent kinase 11A) is mapped to human chromosome 1p36.33. Human genome contains two genes for CDK11, CDK11A and CDK11B. Both genes have three isoforms, the long CDK11^p110, short CDK11^p58 and CDK11^p46. CDK11^p110 is present in the nucleus, CDK11^p58 is present in the nucleus and cytoplasm, and CDK11^p46 is in the cytoplasm. CDK11^p58 is mainly expressed in the G2/M phase. CDK11^p110 is expressed during the whole cell cycle. The CDK11A protein has many NLSs (nuclear localization sequences), a 14-3-3 consensus site, an arginine/glutamic acid domain (RE domain), a poly-glutamic acid domain (poly-E domain) and a carboxy-terminal catalytic domain.

免疫原

PITSLREセリン/スレオニンプロテインキナーゼCDC2L2のPrEST(protein epitope signature tag)抗原リコンビナントタンパク質。

アプリケーション

Prestige抗体^®は、Human Proteome Resource(HPR)プロジェクト(www.proteinatlas.org)によって開発・実証されたAtlas抗体です。抗体はすべて、数百の正常組織・疾病組織に対する免疫組織染色試験を行っています。これらの染色画像はHuman Protein Atlas(HPA)サイトで[Image Gallery]リンクをクリックするとご覧いただけます。さらに、ほとんどのPrestige抗体はプロテインアレイおよびウェスタンブロッティングの試験を行っています。試験のプロトコールおよびPrestige抗体、HPAに関する情報はsigma.com/prestigeをご覧ください。

生物化学的／生理学的作用

CDK11 (cyclin dependent kinase 11) regulates transcription and RNA processing (mainly alternate splicing) by binding to L-type cyclins. It is also involved in cellular responses, such as hormone receptor signaling and autophagy. CDK11^p58 is needed for duplication of the centrioles, spindle rearrangement and sister chromatid cohesion at centromeres. CDK11 plays an important role in cancer cell growth and proliferation by regulating cell death.

特徴および利点

Prestige Antibodies^® are highly characterized and extensively validated antibodies with the added benefit of all available characterization data for each target being accessible via the Human Protein Atlas portal linked just below the product name at the top of this page. The uniqueness and low cross-reactivity of the Prestige Antibodies^® to other proteins are due to a thorough selection of antigen regions, affinity purification, and stringent selection. Prestige antigen controls are available for every corresponding Prestige Antibody and can be found in the linkage section.

Every Prestige Antibody is tested in the following ways:

• IHC tissue array of 44 normal human tissues and 20 of the most common cancer type tissues.
• Protein array of 364 human recombinant protein fragments.

関連事項

Corresponding Antigen APREST76478

物理的形状

PBS溶液(pH 7.2, 40%グリセロールおよび0.02%アジ化ナトリウム含有)。

法的情報

Prestige Antibodies is a registered trademark of Merck KGaA, Darmstadt, Germany

安全性情報

• 保管分類コード: 10 - Combustible liquids
• WGK: WGK 1
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable