HPA002078

抗EIF4ENIF1抗体 ウサギ宿主抗体

Ab2, Prestige Antibodies^® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution

• 別名: 抗4E-T抗体 ウサギ宿主抗体, 抗eIF4E輸送体抗体 ウサギ宿主抗体, 抗真核生物翻訳開始因子4E核内移行因子1抗体 ウサギ宿主抗体, 抗真核生物翻訳開始因子4E輸送体抗体 ウサギ宿主抗体
• MDL番号: MFCD09753853
• UNSPSCコード: 12352203
• Human Protein Atlas Number: HPA002078
• NACRES: NA.43

特性

• 由来生物: rabbit
• 品質水準: 100
• 結合体: unconjugated
• 抗体製品の状態: affinity isolated antibody
• 抗体製品タイプ: primary antibodies
• クローン: polyclonal
• 製品種目: Prestige Antibodies^® Powered by Atlas Antibodies
• フォーム: buffered aqueous glycerol solution
• 交差性: human
• テクニック: immunoblotting: 0.04-0.4 μg/mL; immunofluorescence: 0.25-2 μg/mL; immunohistochemistry: 1:50-1:200
• 免疫原配列: SPLEKDSDGLRLLGGRRIGSGRIISARTFEKDHRLSDKDLRDLRDRDRERDFKDKRFRREFGDSKRVFGERRRNDSYTEEEPEWFSAGPTSQSETIELTGFDDKILEEDHKGRKRTRRRTASVKEGIVECNGGVAEEDEVE
• UniProtアクセッション番号: Q9NRA8
• 輸送温度: wet ice
• 保管温度: −20°C
• ターゲットの翻訳後修飾: unmodified
• 遺伝子情報: human ... EIF4ENIF1(56478)

詳細

詳細

EIF4ENIF1 (eukaryotic translation initiation factor 4E nuclear import factor 1) is a nucleocytoplasmic shuttling protein mainly associated with the cell growth control. It has an eIF4E (eukaryotic initiation factor 4E)-binding site, one bipartite nuclear localization signal and two leucine-rich nuclear export signals. It is localized to the nucleus of mammalian cells and is also concentrated in the processing bodies (P-bodies) i.e. mRNA decay site.

免疫原

eIF4E輸送体のPrEST (protein epitope signature tag)抗原リコンビナントタンパク質。

アプリケーション

Prestige抗体^®は、Human Proteome Resource(HPR)プロジェクト(www.proteinatlas.org)によって開発・実証されたAtlas抗体です。抗体はすべて、数百の正常組織・疾病組織に対する免疫組織染色試験を行っています。これらの染色画像はHuman Protein Atlas(HPA)サイトで[Image Gallery]リンクをクリックするとご覧いただけます。さらに、ほとんどのPrestige抗体はプロテインアレイおよびウェスタンブロッティングの試験を行っています。試験のプロトコールおよびPrestige抗体、HPAに関する情報はsigma.com/prestigeをご覧ください。

生物化学的／生理学的作用

The nucleocytoplasmic transport of EIF4ENIF1 (eukaryotic translation initiation factor 4E nuclear import factor 1) via nuclear pore complex (NPC) is dependent on various nuclear localization signals (NLSs), nuclear export signals (NESs). It mediates the nuclear import of eIF4E (eukaryotic translation initiation factor 4E). During the import it interacts with the importin αβ pathway in piggy-back mechanism manner. It controls the maturation of mRNA and mRNA half-life. Mutation in the gene causes Primary ovarian insufficiency (POI), a premature ovarian failure.

特徴および利点

Prestige Antibodies^® are highly characterized and extensively validated antibodies with the added benefit of all available characterization data for each target being accessible via the Human Protein Atlas portal linked just below the product name at the top of this page. The uniqueness and low cross-reactivity of the Prestige Antibodies^® to other proteins are due to a thorough selection of antigen regions, affinity purification, and stringent selection. Prestige antigen controls are available for every corresponding Prestige Antibody and can be found in the linkage section.

Every Prestige Antibody is tested in the following ways:

• IHC tissue array of 44 normal human tissues and 20 of the most common cancer type tissues.
• Protein array of 364 human recombinant protein fragments.

関連事項

Corresponding Antigen APREST73540

物理的形状

PBS溶液 (pH 7.2, 40%グリセロ-ルおよび0.02%アジ化ナトリウム含有)。

法的情報

Prestige Antibodies is a registered trademark of Merck KGaA, Darmstadt, Germany

安全性情報

• 保管分類コード: 10 - Combustible liquids
• WGK: WGK 1
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable
• 個人用保護具 (PPE): Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)