H0417

Heparin Cofactor II from human plasma

aqueous glycerol solution, ≥90% (SDS-PAGE)

• 別名: HCF2, HCII, SERPIND1
• CAS番号: 81604-65-1
• MDL番号: MFCD00285907
• UNSPSCコード: 12352202
• NACRES: NA.61

特性

• 由来生物: human plasma
• 品質水準: 200
• アッセイ: ≥90% (SDS-PAGE)
• 形状: aqueous glycerol solution
• 分子量: ~66 kDa; ~66 kDa
• NCBIアクセッション番号: NP_000176
• 輸送温度: wet ice
• 保管温度: −20°C
• 遺伝子情報: human ... SERPIND1(3053)

詳細

生物化学的／生理学的作用

Heparin cofactor II (HCII), a member of the serpin superfamily, is a serine protease inhibitor that rapidly inactivates thrombin in the presence of dermatan sulfate, heparan sulfate, or heparin. In addition to its role in coagulation regulation, HCII may also participate in inflammation, atherosclerosis, and wound repair. For example, leukocyte-mediated degradation of HCII releases peptides that are chemotactic for neutrophils and monocytes which may promote acute inflammation and wound repair. It has also been reported that HCII and dermatan sulfate levels are elevated in pregnancy, suggesting that HCII may be protective against thrombosis during pregnancy.

Serine protease that inhibits thrombin, α-chymotrypsin, neutrophil cathepsin G, and Streptomyces griseus protease B.

単位の定義

HCII is tested for activity using a Thrombin inhibition assay. One unit will inhibit one NIH unit of Thrombin.

物理的形状

50% aqueous glycerol solution (vol/vol)

免責事項

RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.

安全性情報

• 保管分類コード: 10 - Combustible liquids
• WGK: WGK 1
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable