GS75

GST O1-1, Recombinant Human

• 別名: GSTO 1-1, GSTTLp28, HEL-S-21, P28, SPG-R, glutathione S-transferase omega 1
• UNSPSCコード: 12352200
• NACRES: NA.26

特性

• 由来生物: human
• 品質水準: 100
• リコンビナント: expressed in E. coli
• アッセイ: >95% (SDS-PAGE)
• 形状: frozen liquid
• 比活性: 4.21 units/mg protein
• 分子量: 26 kDa
• 濃度: 1.98 mg/mL
• 保管温度: −70°C
• 遺伝子情報: human ... GSTO1(9446)

詳細

詳細

using spectrophotometric determination of 1-chloro-2,4-dinitrobenzene (CDNB) conjugation with reduced glutathione (1 mM) in 100 mM NaPO4 (pH 6.5) at room temperature.

生物化学的／生理学的作用

Glutathione S-transferase omega 1 (GSTO1) is an enzyme that in humans is encoded by the GSTO1 gene. Glutathione S-transferases (GSTs) are a family of enzymes that play an important role in detoxification by catalyzing the conjugation of many hydrophobic and electrophilic compounds with reduced glutathione. Based on their biochemical, immunologic, and structural properties, cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. The GSTs are thought to function in xenobiotic metabolism and play a role in susceptibility to cancer, and other diseases.

The protein encoded by this gene is an omega class glutathione S-transferase (GST) with glutathione-dependent thiol transferase and dehydroascorbate reductase activities. GSTs are involved in the metabolism of xenobiotics and carcinogens. The encoded protein acts as a homodimer and is found in the cytoplasm. Three transcript variants encoding different isoforms have been found for this gene.

保管および安定性

The enzyme should be used by the end-user customer within 1 year of receipt.

安全性情報

• 保管分類コード: 10 - Combustible liquids
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable