G8918

抗GRP78/BiP (GL-19)抗体 ウサギ宿主抗体

IgG fraction of antiserum, buffered aqueous solution

• 別名: 抗78-kDaグルコース調節タンパク質抗体, 抗イムノグロブリンH鎖結合タンパク質抗体
• MDL番号: MFCD01865530
• UNSPSCコード: 12352203
• NACRES: NA.41

特性

• 由来生物: rabbit
• 結合体: unconjugated
• 抗体製品の状態: IgG fraction of antiserum
• 抗体製品タイプ: primary antibodies
• クローン: polyclonal
• 形状: buffered aqueous solution
• 分子量: antigen 78 kDa
• 化学種の反応性: mouse, hamster, human
• 強化検証: independent; Learn more about Antibody Enhanced Validation
• テクニック: immunocytochemistry: 1:1,000 using mouse fibroblasts NIH3T3 cells; microarray: suitable; western blot: 1:3,000 using human epitheloid carcinoma HeLa whole cell extract
• UniProtアクセッション番号: P11021
• 輸送温度: dry ice
• 保管温度: −20°C
• ターゲットの翻訳後修飾: unmodified
• 遺伝子情報: human ... HSPA5(3309) ; mouse ... Hspa5(14828)

詳細

詳細

GRP78/BiP is a Ca²⁺-binding molecular chaperone located in the endoplasmic reticulum (ER). It is a highly conserved protein.

アプリケーション

Anti-GRP78/BiP (GL-19) antibody produced in rabbit has been used in:

• western blotting
• immunocytochemistry
• immunohistochemistry

生物化学的／生理学的作用

GRP78 (78-kDa glucose-regulated protein) is essential for cell viability. GRP78/BiP is induced by stress-inducing agents or by conditions that adversely affect endoplasmic reticulum(ER) function, including oxidative stress, chemical toxicity, Ca²⁺ ionophores, inhibition of the ER Ca²⁺ -ATPase, inhibitors of glycosylation and hypoxia. GRP78/BiP is critical for maintenance of Ca²⁺ homeostasis and the prevention of apoptosis. GRP78/BiP levels are reduced in Alzheimer′s disease brains and the decreased expression of GRP78/BiP is found associated with mis-sense mutations in presenilin-1 (PS-1).

物理的形状

0.01M PBS溶液 (pH 7.4, 15mMアジ化ナトリウム含有)。

免責事項

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全性情報

• 保管分類コード: 10 - Combustible liquids
• WGK: nwg
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable