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由来生物
rabbit
品質水準
結合体
unconjugated
抗体製品の状態
affinity isolated antibody
抗体製品タイプ
primary antibodies
クローン
polyclonal
フォーム
buffered aqueous solution
分子量
antigen 72 kDa
化学種の反応性
mouse, rat, human
濃度
~1 mg/mL
テクニック
ELISA: 1:5000
immunofluorescence: 1:100-1:500
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000
NCBIアクセッション番号
UniProtアクセッション番号
輸送温度
wet ice
保管温度
−20°C
ターゲットの翻訳後修飾
unmodified
遺伝子情報
human ... HSPA5(3309)
詳細
Glucose/regulated protein 78 (GRP78) is a stress-associated protein. It is mapped to human chromosome 9q33.3. It is also known as HSPA5 (heat shock 70kDa protein 5) and immunoglobulin heavy chain binding protein (BiP). It is present in nucleated cells like thyroid, lung, smooth muscle, liver and several cells of the immune system.
The molecular weight of GRP78 is 78kDa.
免疫原
The antiserum was produced against synthesized peptide derived from human GRP78.
Immunogen Range: 605-654
Immunogen Range: 605-654
生物化学的／生理学的作用
GRP78 levels are elevated during various human cancers and tumors.
Glucose/regulated protein 78 (GRP78) participates in stress-associated diseases. It also participates in protein biogenesis (protein transport into the endoplasmic reticulum (ER), protein folding and assembly and ER associated protein degradation), signal transduction and calcium homeostasis.
特徴および利点
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
物理的形状
ウサギIgGのPBS溶液（Mg2+およびCa2+を含まず）、pH 7.4、150 mM NaCl、0.02％ アジ化ナトリウム、50％ グリセロール
免責事項
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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保管分類コード
10 - Combustible liquids
WGK
nwg
引火点(°F)
Not applicable
引火点(℃)
Not applicable
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
Jan Code
SAB4501452-100UG:
最新バージョンのいずれかを選択してください：
Role of the unfolded protein response regulator GRP78/BiP in development, cancer, and neurological disorders
Wang M, et al.
Antioxidants & Redox Signaling, 11(9), 2307-2316 (2009)
Overexpression of the glucose-regulated stress gene GRP78 in malignant but not benign human breast lesions
Fernandez P M, et al.
Breast Cancer Research and Treatment, 59(1), 15-26 (2000)
Eman Radwan et al.
Journal of molecular and cellular cardiology, 143, 15-25 (2020-04-21)
Metabolic (Met) syndrome is characterized by hypertension, insulin resistance and dyslipidaemia with high risk of cardiovascular disease. Endoplasmic reticulum (ER) stress is a key contributor in the pathogenesis of Met syndrome. The current study investigates the effect of Tauroursodeoxycholate (TUDCA)
Lin Ma et al.
Biochemical and biophysical research communications, 533(4), 1449-1456 (2020-11-11)
DEAD-Box Helicase 5(DDX5), also known as P68, is one of the founding members of the DEAD-Box helicase superfamily and it plays a key role in RNA metabolism. Several studies have reported that DDX5 is involved in many types of tumors
HSPA5 (heat shock 70kDa protein 5 (glucoseregulated protein, 78kDa)).
Zimmermann R and Dudek J
Atlas of Genetics and Cytogenetics in Oncology and Haematology (2010)
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