G117

グリピジド

solid

• 別名: 1-シクロヘキシル-3-{4-[2-(5-メチルピラジン-2-カルボキサミド)エチル]フェニルスルホニル}尿素
• 実験式（ヒル表記法）: C₂₁H₂₇N₅O₄S
• CAS番号: 29094-61-9
• 分子量: 445.54
• EC Number: 249-427-6
• MDL番号: MFCD00072159
• UNSPSCコード: 12352200
• PubChem Substance ID: 24277839
• NACRES: NA.77

特性

• 形状: solid
• 色: white
• 溶解性: methanol: 1.9 mg/mL; DMSO: 48 mg/mL
• SMILES記法: Cc1cnc(cn1)C(=O)NCCc2ccc(cc2)S(=O)(=O)NC(=O)NC3CCCCC3
• InChI: 1S/C21H27N5O4S/c1-15-13-24-19(14-23-15)20(27)22-12-11-16-7-9-18(10-8-16)31(29,30)26-21(28)25-17-5-3-2-4-6-17/h7-10,13-14,17H,2-6,11-12H2,1H3,(H,22,27)(H2,25,26,28)
• InChI Key: ZJJXGWJIGJFDTL-UHFFFAOYSA-N
• 遺伝子情報: human ... ABCC8(6833) , KCNJ1(3758) , KCNJ11(3767)

詳細

詳細

Potassium inwardly-rectifying channel, subfamily J, member 1 (KCNJ1) codes for a renal outer medullary potassium channel (ROMK1, Kir1.1). Glipizide is an antidiabetic drug, that is used to treat type II diabetes.(5)

アプリケーション

Glipizide has been used in:

• chick embryo yolk sac membrane (YSM) and chorioallantoic membrane (CAM) assay
• MCF-7 breast cancer assay on chorioallantoic membrane (CAM)
• metastasis assays
• rat aortic ring assay
• in vivo matrigel plug assay
• 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) assay
• flow cytometry
• western blotting

生物化学的／生理学的作用

Potassium inwardly-rectifying channel, subfamily J, member 1 (KCNJ1) plays a vital role in potassium balance. It is an ATP-dependent K⁺ channel blocker. The encoded protein is liable for the elimination of potassium in exchange for the absorption of sodium by the epithelial sodium channel (ENaC). Mutation in KCNJ1 is linked with several diseases, such as, antenatal Bartter syndrome and diabetes. Glipizide helps to repress the development of tumors and metastasis by preventing angiogenesis.

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable
• 個人用保護具 (PPE): Eyeshields, Gloves, type N95 (US)