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Merck

F1054

Sigma-Aldrich

抗FOXC2抗体 ウサギ宿主抗体

affinity isolated antibody, buffered aqueous solution

別名:

抗FKHL14抗体

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About This Item

MDL番号:
UNSPSCコード:
12352203
NACRES:
NA.41
クローン:
polyclonal
application:
ARR
WB
化学種の反応性:
human, mouse
テクニック:
microarray: suitable
western blot: 1-2 μg/mL using total extracts of NIH3T3-L1 cells
citations:
5

由来生物

rabbit

品質水準

結合体

unconjugated

抗体製品の状態

affinity isolated antibody

抗体製品タイプ

primary antibodies

クローン

polyclonal

フォーム

buffered aqueous solution

分子量

antigen ~55 kDa

化学種の反応性

human, mouse

テクニック

microarray: suitable
western blot: 1-2 μg/mL using total extracts of NIH3T3-L1 cells

UniProtアクセッション番号

輸送温度

dry ice

保管温度

−20°C

ターゲットの翻訳後修飾

unmodified

遺伝子情報

human ... FOXC2(2303)
mouse ... Foxc2(14234)

免疫原

synthetic peptide corresponding to amino acids 439-454 of mouse FOXC2, conjugated to KLH via an N-terminal added lysine residue. The immunizing sequence is conserved in human and mouse. The sequence is partially conserved in FOXC1, another member of Forkhead family.

アプリケーション

Anti-FOXC2 antibody produced in rabbit is suitable for microarray and western blotting at a concentration of 1-2μg/mL using total extracts of NIH3T3-L1 cells.

生物化学的/生理学的作用

Forkhead box protein C2 (FOXC2) is a protein encoded by the FOXC2 gene in humans. It is a member of the fork head box (FOX) family of transcription factors and acts as a positive transactivator. FOXC2 is expressed in somitic mesoderm, the endocardium and blood vessels as well as the condensing mesenchyme of the bones and kidney and in head mesenchyme. It induces epithelial-to-mesenchymal transition (EMT), which is an important step in Extrahepatic cholangiocarcinoma (EHCC) invasion and metastasis. FOXC2 may act as a promising molecular target for regulating EHCC metastasis. It is mutated in the human vascular disease lymphedema-distichiasis and plays an essential role in lymphatic vascular development. FOXC2 gene expression may provide an effective target for anti-EMT-based therapies for the treatment of claudin-low/basal B breast tumors or other EMT-/CSC-enriched tumors.

物理的形状

Solution in 0.01 M phosphate buffered saline, pH 7.4, and 15 mM sodium azide.

免責事項

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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保管分類コード

10 - Combustible liquids

WGK

WGK 3

引火点(°F)

Not applicable

引火点(℃)

Not applicable


適用法令

試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。

Jan Code

IXO11596:
F1054-VAR:
F1054-200UL:
F1054-BULK:


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試験成績書(COA)

Lot/Batch Number

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文書ライブラリにアクセスする

X L Yang et al.
FEBS letters, 470(1), 29-34 (2000-03-21)
Mesenchyme forkhead-1 (MFH-1), a winged helix/forkhead transcription factor, is expressed in developing cartilaginous tissues, kidney and arch arteries, and is essential for the normal development of the axial skeleton and aortic arch formation of mice. To investigate the possible role
Akira Watanabe et al.
Cancer science, 104(11), 1427-1432 (2013-08-08)
Extrahepatic cholangiocarcinoma (EHCC) is a cancer with a poor prognosis, and the postoperative survival of patients depends on the existence of invasion and metastasis. The epithelial-to-mesenchymal transition (EMT) is an important step in EHCC invasion and metastasis. Forkhead box protein
Brett G Hollier et al.
Cancer research, 73(6), 1981-1992 (2013-02-05)
Resistance to chemotherapy and metastases are the major causes of breast cancer-related mortality. Moreover, cancer stem cells (CSC) play critical roles in cancer progression and treatment resistance. Previously, it was found that CSC-like cells can be generated by aberrant activation
Maria K Dahle et al.
The Journal of biological chemistry, 277(25), 22902-22908 (2002-04-12)
We have reported recently that mice overexpressing the forkhead/winged helix transcription factor FOXC2 are lean and show increased responsiveness to insulin due to sensitization of the beta-adrenergic cAMP-PKA(+) pathway and increased levels of the RI alpha subunit of cAMP-dependent protein
N Miura et al.
Genomics, 41(3), 489-492 (1997-05-01)
The very recently found evolutionarily conserved DNA-binding domain of 100 amino acids, termed the fork head domain, emerged from a sequence comparison of the rat hepatocyte transcription factor HNF-3 alpha and the homeotic gene fork head of Drosophila. We previously

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