F0756

フシジン酸

• 別名: Ramycin
• 実験式（ヒル表記法）: C₃₁H₄₈O₆
• CAS番号: 6990-06-3
• 分子量: 516.71
• EC Number: 230-256-0
• MDL番号: MFCD00865135
• UNSPSCコード: 12352106
• PubChem Substance ID: 57654174
• NACRES: NA.77

特性

• 保管温度: 2-8°C
• SMILES記法: [H][C@@]12CC[C@@]3(C)[C@@]([H])([C@H](O)C[C@@]4([H])\C([C@H](C[C@]34C)OC(C)=O)=C(/CC\C=C(\C)C)C(O)=O)[C@@]1(C)CC[C@@H](O)[C@H]2C
• InChI: 1S/C31H48O6/c1-17(2)9-8-10-20(28(35)36)26-22-15-24(34)27-29(5)13-12-23(33)18(3)21(29)11-14-30(27,6)31(22,7)16-25(26)37-19(4)32/h9,18,21-25,27,33-34H,8,10-16H2,1-7H3,(H,35,36)/b26-20-/t18-,21-,22-,23+,24+,25-,27-,29-,30-,31-/m0/s1
• InChI Key: IECPWNUMDGFDKC-MZJAQBGESA-N

詳細

アプリケーション

Fusidic acid has been used:

• as a standard in thin-layer chromatography (TLC)-densitometric method
• to study its ability to bind to human serum albumin
• as an antibiotic in combination with tannic acid to determine minimum inhibitory concentrations (MIC) in methicillin-resistant Staphylococcus aureus (MRSA)

生物化学的／生理学的作用

膵島細胞の一酸化窒素による溶解を抑制します。伸長因子Gのリボソ-ム依存的活性の阻害とペプチジルtRNAの転移阻害により、原核生物のタンパク質合成を阻害します。

Fusidic acid is a tetracyclic triterpenoid with antibiotic activity against Gram-positive bacteria. It is derived from Fusidium coccineum. It shows its activity against anaerobes, corynebacterial, Nocardia, and Neisseria species. Fusidic acid exhibits therapeutic effects against Staphylococcal infections, skin infections.

安全性情報

• ピクトグラム: GHS07
• シグナルワード: Warning
• 危険有害性情報: H302
• 注意書き: P264 - P270 - P301 + P312 + P330 - P501
• 危険有害性の分類: Acute Tox. 4 Oral
• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable
• 個人用保護具 (PPE): dust mask type N95 (US), Eyeshields, Gloves