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主要文書

EHU035531

MISSION^® esiRNA

Name: MISSION<SUP>®</SUP> esiRNA
Brand: SIGMA

targeting human UPF1

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About This Item

UNSPSCコード:

41105324

NACRES:

NA.51

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Sigma-Aldrich

EHU038621

MISSION^® esiRNA

DWK92812G-2000

KIMBLE^® KIMAX^® Heavy duty volumetric wide-mouth flask with glass stopper

Sigma-Aldrich

ABS2183M

Anti-Coagulation factor VIIa

Sigma-Aldrich

213438

水素化ホウ素トリエチルカリウム溶液

Sigma-Aldrich

288462

三臭化リン

Sigma-Aldrich

745979

tBuBrettPhos Pd G3

Sigma-Aldrich

S5761

重炭酸ナトリウム

Z740269

Thermal transfer labels, Xylene resistant

Supelco

1.04936

塩化カリウム

Sigma-Aldrich

M4526

イーグル最少必須培地

詳細

品質水準

100

製品種目

MISSION^®

フォーム

lyophilized powder

esiRNA cDNA標的配列

GGACGCCTACCAGTACCAGAACATATTCGGGCCCCTGGTCAAGCTGGAGGCCGACTACGACAAGAAGCTGAAGGAGTCCCAGACTCAAGATAACATCACTGTCAGGTGGGACCTGGGCCTTAACAAGAAGAGAATCGCCTACTTCACTTTGCCCAAGACTGACTCTGACATGCGGCTCATGCAGGGGGATGAGATATGCCTGCGGTACAAAGGGGACCTTGCGCCCCTGTGGAAAGGGATCGGCCACGTCATCAAGGTCCCTGATAATTATGGCGATGAGATCGCCATTGAGCTGCGGAGCAGCGTGGGTGCACCTGTGGAGGTGACTCACAACTTCCAGGTGGATTTTGTGTGGAAGTCGACCTCCTTTGACAGGATGCAGAGCGCATTGAAAACGTTTGCCGTGGATGAGACCTCGGTGTCTGGCTACATCTACCACAAGCTGTTGGGCCACGAGGTGGAGGACGTAAT

Ensembl |ヒトアクセッション番号

ENSG00000005007

NCBIアクセッション番号

NM_002911

輸送温度

ambient

保管温度

−20°C

遺伝子情報

human ... UPF1(5976) , UPF1(5976)

詳細

MISSION^® esiRNA are endoribonuclease prepared siRNA. They are a heterogeneous mixture of siRNA that all target the same mRNA sequence. These multiple silencing triggers lead to highly-specific and effective gene silencing.

For additional details as well as to view all available esiRNA options, please visit SigmaAldrich.com/esiRNA.

法的情報

MISSION is a registered trademark of Merck KGaA, Darmstadt, Germany

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保管分類コード

10 - Combustible liquids

引火点(°F)

Not applicable

引火点(℃)

Not applicable

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K120R mutation inactivates p53 by creating an aberrant splice site leading to nonsense-mediated mRNA decay.

Seo-Young Lee et al.

Oncogene, 38(10), 1597-1610 (2018-10-24)

The point mutation that substitutes lysine with arginine at position 120 of human p53 has been characterized as a missense mutation. The K120R mutation renders the p53 protein disabled for acetylation and, as a result, defective for apoptotic function, which

Endoplasmic Reticulum Stress in Mice Increases Hepatic Expression of Genes Carrying a Premature Termination Codon via a Nutritional Status-Independent GRP78-Dependent Mechanism.

Nagakatsu Harada et al.

Journal of cellular biochemistry, 118(11), 3810-3824 (2017-04-07)

Nonsense-mediated mRNA decay (NMD) degrades mRNAs carrying a premature termination codon (PTC) in eukaryotes. Cellular stresses, including endoplasmic reticulum (ER) stress, inhibit NMD, and up-regulate PTC-containing mRNA (PTC-mRNA) levels in several cell lines. However, whether similar effects exist under in

Activation and inhibition of nonsense-mediated mRNA decay control the abundance of alternative polyadenylation products.

Aparna Kishor et al.

Nucleic acids research, 48(13), 7468-7482 (2020-06-17)

Alternative polyadenylation (APA) produces transcript 3' untranslated regions (3'UTRs) with distinct sequences, lengths, stabilities and functions. We show here that APA products include a class of cryptic nonsense-mediated mRNA decay (NMD) substrates with extended 3'UTRs that gene- or transcript-level analyses

Long noncoding RNA MACC1-AS1 promotes the stemness of nonsmall cell lung cancer cells through promoting UPF1-mediated destabilization of LATS1/2.

Xiaojun Wang et al.

Environmental toxicology, 35(9), 998-1006 (2020-05-14)

The roles of long noncoding RNA (lncRNA) MACC1-AS1 have been revealed in various tumors. This work aims to explore the roles of lncRNA MACC1-AS1 in the stemness of nonsmall cell lung cancer (NSCLC) cells and the underlying mechanism. We showed

SERPING1 exon 3 splicing variants using alternative acceptor splice sites.

Tereza Grymová et al.

Molecular immunology, 107, 91-96 (2019-01-28)

Mutations in the C1 inhibitor (C1INH) encoding gene, SERPING1, are associated with hereditary angioedema (HAE) which manifests as recurrent submucosal and subcutaneous edema episodes. The major C1INH function is the complement system inhibition, preventing its spontaneous activation. The presented study

主要文書

MISSION^® esiRNA