UPF1
UPF1 regulator of nonsense transcripts homolog (yeast)
Synonyms:
HUPF1, NORF1, RENT1, pNORF1, smg-2
Species:
Human UPF1 (5976), Mouse Upf1 (19704), Rat Upf1 (684558), fruit fly Upf1 (32153), chicken UPF1 (420119), dog UPF1 (476664), Horse UPF1 (100071059), domestic cat UPF1 (101096043), Zebrafish upf1 (406783), naked mole-rat Upf1 (101704366) ...More
UniProtKB ID:
Gene ID:
- Human(5976) Summary: This gene encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein is located only in the cytoplasm. When translation ends, it interacts with the protein that is a functional homolog of yeast Upf2p to trigger mRNA decapping. Use of multiple polyadenylation sites has been noted for this gene. [provided by RefSeq, Jul 2008]
- Mouse(19704) UPF1 regulator of nonsense transcripts homolog (yeast)
- Rat(684558) UPF1 regulator of nonsense transcripts homolog (yeast)
- fruit fly(32153) CG1559 gene product from transcript CG1559-RA
- chicken(420119) UPF1 regulator of nonsense transcripts homolog (yeast)
- dog(476664) UPF1 regulator of nonsense transcripts homolog (yeast)
- Horse(100071059) UPF1 regulator of nonsense transcripts homolog (yeast)
- domestic cat(101096043) UPF1 regulator of nonsense transcripts homolog (yeast)
- Zebrafish(406783) upf1 regulator of nonsense transcripts homolog (yeast)
- naked mole-rat(101704366) UPF1 regulator of nonsense transcripts homolog (yeast)
- domestic guinea pig(100713813) UPF1 regulator of nonsense transcripts homolog (yeast)
- cow(532933) UPF1 regulator of nonsense transcripts homolog (yeast)
- sheep(101107598) UPF1 regulator of nonsense transcripts homolog (yeast)
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Antibodies
Product Number
Description
Species Reactivity
Application
Monoclonal Anti-UPF1 antibody produced in mouse, clone 4G3, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
ELISA
western blot
western blot
Anti-UPF1 antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
bovine, dog, human
Application
immunohistochemistry
western blot
western blot
Anti-UPF1 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution, Ab2,
Species Reactivity
human
Application
immunohistochemistry
Anti-UPF1 antibody produced in rabbit, affinity isolated antibody, buffered aqueous glycerol solution, Ab1,
Species Reactivity
human, mouse, rat
Application
immunofluorescence
immunohistochemistry
western blot
immunohistochemistry
western blot
Goat anti-RENT1 Antibody, Affinity Purified, Powered by Bethyl Laboratories, Inc.,
Species Reactivity
human, mouse
Application
immunoprecipitation (IP)
western blot
western blot