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由来生物
mouse
品質水準
リコンビナント
expressed in NSO cells
アッセイ
>90% (SDS-PAGE)
フォーム
lyophilized powder
有効性
0.16-10 ng/mL
分子量
monomer calculated mol wt 46.8 kDa
50-55 kDa by SDS-PAGE (reducing)
包装
pkg of 200 μg
保管条件
avoid repeated freeze/thaw cycles
不純物
endotoxin, tested
UniProtアクセッション番号
保管温度
−20°C
遺伝子情報
mouse ... Efna1(13636)
生物化学的／生理学的作用
Eph受容体チロシンキナ-ゼ (EphA1, EphA2, EphA3, EphA4, EphA5, EphA6, EphA7, EphB1) に結合するエフリンリガンドファミリ-メンバ-です。パタ-ン形成および形態形成に関与します。エフリン-A1は胎児骨芽細胞、象牙芽細胞、軟骨細胞、扁平上皮で検出できます。Ephrin-A1は、胚の脈管形成時と腫瘍による血管新生時に発現されます。
EphA1 (ephrin receptor A1) plays an essential role in development, and is involved in the guidance of axonal and cell migration in nervous system. Disruption of ephrin signaling might be involved in the tumorigenesis of clear cell renal cell carcinoma, and absence of EphA1 has a favorable prognosis in the same. It might also be involved in the tumorigenesis and progression of prostate cancer, and might have potential as a marker for prognosis, as well as a therapeutic target. Studies show that it reduces the risk of Alzheimer′s disease, by hindering pathological changes in brain areas such as, hippocampus, lateral occipitotemporal and inferior temporal gyri. In esophageal squamous cells, it acts as differentiation marker. Its expression is elevated in esophageal squamous cell carcinoma, and this relates to advanced stage and metastasis to lymph node.
その他情報
マウスephrin-A1(アミノ酸配列1-182)の細胞外ドメインに、6Xヒスチジンタグをカルボキシル末端に付けたヒトIgGのFc領域を融合しました。
物理的形状
凍結乾燥品 (PBS溶液, 0.2μmフィルタ-濾過)。
アナリシスノート
生物活性はマウスEphA2/Fc組み換え体への結合能をELISA法で測定しています。
保管分類コード
11 - Combustible Solids
WGK
WGK 3
引火点(°F)
Not applicable
引火点(℃)
Not applicable
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
Jan Code
E9902-200UG-PW:
E9902-200UG:
E9902-VAR:
E9902-BULK:
Hui-Fu Wang et al.
Journal of Alzheimer's disease : JAD, 44(1), 115-123 (2014-09-04)
Ephrin type-A receptor 1 (EPHA1) (11771145) was documented to be one of the most strongly associated locus with Alzheimer's disease (AD) in a recent meta-analysis of five genome wide association studies. However, its contribution to the pathogenesis of AD remains
Augustin DuSablon et al.
PloS one, 12(12), e0189307-e0189307 (2017-12-14)
EphrinA1, a membrane-bound receptor tyrosine kinase ligand expressed in healthy cardiomyocytes, is lost in injured cells following myocardial infarction. Previously, we have reported that a single intramyocardial injection of chimeric ephrinA1-Fc at the time of ischemia reduced injury in the
Libo Peng et al.
International journal of clinical and experimental pathology, 6(9), 1854-1860 (2013-09-17)
The erythropoietin-producing hepatocellular (Eph) family of receptor tyrosine kinases regulates a multitude of physiological and pathological processes. EphA1 is the first member of Eph superfamily and is involved in carcinogenesis. The aim of this study was to investigate the expression
Matthieu Chavent et al.
Biochemistry, 53(42), 6641-6652 (2014-10-07)
EphA1 is a receptor tyrosine kinase (RTK) that plays a key role in developmental processes, including guidance of the migration of axons and cells in the nervous system. EphA1, in common with other RTKs, contains an N-terminal extracellular domain, a
Jiandong Wang et al.
APMIS : acta pathologica, microbiologica, et immunologica Scandinavica, 121(1), 30-37 (2012-10-04)
Eph receptors play important roles in the development of cancer. The present study aimed to investigate the expression of EphA1 and its clinicopathologic significance in esophageal squamous cell carcinoma (ESCC). The expression levels of the EphA1 transcript and protein were
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