E3888

[D-Pen^2,5]-エンケファリン 水和物

≥95% (HPLC)

• 別名: DPDPE
• 実験式（ヒル表記法）: C₃₀H₃₉N₅O₇S₂ · xH₂O
• 分子量: 645.79 (anhydrous basis)
• MDL番号: MFCD00076430
• UNSPSCコード: 12352209
• PubChem Substance ID: 329799055
• NACRES: NA.32

特性

• 品質水準: 200
• アッセイ: ≥95% (HPLC)
• 保管温度: −20°C
• SMILES記法: CC1(C)SSC(C)(C)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)C(=O)NCC(=O)N[C@@H](Cc3ccccc3)C(=O)N[C@H]1C(O)=O
• InChI: 1S/C30H39N5O7S2/c1-29(2)23(34-25(38)20(31)14-18-10-12-19(36)13-11-18)27(40)32-16-22(37)33-21(15-17-8-6-5-7-9-17)26(39)35-24(28(41)42)30(3,4)44-43-29/h5-13,20-21,23-24,36H,14-16,31H2,1-4H3,(H,32,40)(H,33,37)(H,34,38)(H,35,39)(H,41,42)/t20-,21-,23-,24-/m0/s1
• InChI Key: MCMMCRYPQBNCPH-WMIMKTLMSA-N

詳細

Amino Acid Sequence

Tyr-Pen-Gly-Phe-Pen [Disulfide Bridge: 2-5]

詳細

[D-Pen^2,5]-Enkephalin hydrate, also called DPDPE, is a peptide and acts as a δ1-opioid receptor agonist. Opioid receptors are divided into three types called, μ, κ and δ, depending upon their ligands. These ligands are peptides and are classified as enkephalins, endorphins and dynorphins.

アプリケーション

[D-Pen^2,5]-Enkephalin hydrate (DPDPE) has been used to study the pharmacodynamic and pharmacokinetic capabilities of polyethylene glycol (PEG) conjugate of DPDPE in rodents. It has been used to study the tendency of opiate self-administration in male Long-Evans rats, in ventral tegmental area (VTA).

生物化学的／生理学的作用

δ₁受容体を介する抗侵害受容作用と同時に、δ₂受容体を介した調節作用を有します。トリチウム標識した[D-Pen^2,5]-エンケファリンはδ₁リガンドとして用いられます。

その他情報

Lyophilized from 0.1% TFA in H2O

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable
• 個人用保護具 (PPE): Eyeshields, Gloves, type N95 (US)