E1657

EHT 1864

≥98% (HPLC)

• 別名: 5-(5-(7-(トリフルオロメチル)キノリン-4-イルチオ)ペンチルオキシ)-2-(モルホリノメチル)-4H-ピラン-4-オン二塩酸塩
• 実験式（ヒル表記法）: C₂₅H₂₇F₃N₂O₄S · 2HCl
• CAS番号: 754240-09-0
• 分子量: 581.47
• MDL番号: MFCD11114384
• UNSPSCコード: 12352200
• PubChem Substance ID: 329799014
• NACRES: NA.77

特性

• アッセイ: ≥98% (HPLC)
• 形状: powder
• 色: white to beige
• 溶解性: H₂O: 10 mg/mL, clear
• 保管温度: 2-8°C
• SMILES記法: Cl.Cl.FC(F)(F)c1ccc2c(SCCCCCOC3=COC(CN4CCOCC4)=CC3=O)ccnc2c1
• InChI: 1S/C25H27F3N2O4S.2ClH/c26-25(27,28)18-4-5-20-21(14-18)29-7-6-24(20)35-13-3-1-2-10-33-23-17-34-19(15-22(23)31)16-30-8-11-32-12-9-30;;/h4-7,14-15,17H,1-3,8-13,16H2;2*1H
• InChI Key: LSECOAJFCKFQJG-UHFFFAOYSA-N

詳細

アプリケーション

EHT 1864 has been used to study the regulation of the adapter protein dishevelled-1 ubiquitylation by Rac1 activity.

生物化学的／生理学的作用

EHT 1864はRacの機能を阻害します。in vitroにおいてγ-セクレターゼを直接阻害せずにAβ40やAβ42の産生を阻止します。

EHT 1864 induces dissociation of bound nucleotides. EHT 1864 induced inhibition of Rac prevents its association with downstream effectors. It is known to prevent estrogen-induced tumor cell proliferation in breast cancer.

特徴および利点

This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the GTP Binding Proteins (Low Molecular Weight) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

法的情報

EHT 1864はExonHit Therapeutics S.A.(www.exonhit.com)の特許ライセンスを受けて販売を行っています。

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable
• 個人用保護具 (PPE): Eyeshields, Gloves, type N95 (US)