D9696

ドロネダロン 塩酸塩

≥98% (HPLC)

• 別名: Multaq, SR-33589B
• 実験式（ヒル表記法）: C₃₁H₄₄N₂O₅S · HCl
• CAS番号: 141625-93-6
• 分子量: 593.22
• MDL番号: MFCD00914940
• UNSPSCコード: 12352200
• PubChem Substance ID: 329798909
• NACRES: NA.77

特性

• 品質水準: 100
• アッセイ: ≥98% (HPLC)
• フォーム: powder
• 保管条件: desiccated
• 色: white to off-white
• 溶解性: DMSO: 15 mg/mL, clear
• オーガナイザー: Sanofi Aventis
• 保管温度: 2-8°C
• SMILES記法: Cl.CCCCN(CCCC)CCCOc1ccc(cc1)C(=O)c2c(CCCC)oc3ccc(NS(C)(=O)=O)cc23
• InChI: 1S/C31H44N2O5S.ClH/c1-5-8-12-29-30(27-23-25(32-39(4,35)36)15-18-28(27)38-29)31(34)24-13-16-26(17-14-24)37-22-11-21-33(19-9-6-2)20-10-7-3;/h13-18,23,32H,5-12,19-22H2,1-4H3;1H
• InChI Key: DWKVCQXJYURSIQ-UHFFFAOYSA-N
• 遺伝子情報: human ... CACNA1C(775) , CACNA1D(776) , CACNA1F(778) , CACNA1S(779) , HCN4(10021) , KCNJ2(3759) , SCN10A(6336) , SCN11A(11280) , SCN1A(6323) , SCN2A(6326) , SCN3A(6328) , SCN4A(6329) , SCN5A(6331) , SCN7A(6332) , SCN8A(6334) , SCN9A(6335)

詳細

アプリケーション

Dronedarone hydrochloride has been used as an anti-arrhythmic drug to assess its impact in P19C5 embryoid bodies (EBs). It has also been used to determine its antiviral potency.

生物化学的／生理学的作用

ドロネダロンは、クラスIIIの抗不整脈薬であり、心房細動のためのマルチチャネル遮断薬です。カリウム、ナトリウム、カルシウムチャネルを遮断し、また、抗アドレナリン特性も示します。

Dronedarone is a synthetic derivative of amiodarone, which belongs to the class of benzofurane anti-arrhythmic compounds. It might moderately block cytochrome P450 3A4 (CYP3A4) activity. Dronedarone is used to treat atrial flutter.

特徴および利点

This compound is featured on the Potassium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Sanofi Aventis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable