D2390

ダカルバジン

antineoplastic purine analog

• 別名: 5-(3,3-ジメチル-1-トリアゼニル)イミダゾール-4-カルボキサミド, DTIC
• 実験式（ヒル表記法）: C₆H₁₀N₆O
• CAS番号: 4342-03-4
• 分子量: 182.18
• EC Number: 224-396-1
• MDL番号: MFCD00057167
• UNSPSCコード: 51102829
• PubChem Substance ID: 24893683
• NACRES: NA.85

特性

• 形状: powder or crystals
• 溶解性: 1 M HCl: 50 mg/mL
• 抗生物質活性スペクトル: neoplastics
• 作用機序: DNA synthesis | interferes
• 保管温度: 2-8°C
• SMILES記法: CN(C)\N=N\c1[nH]cnc1C(N)=O
• InChI: 1S/C6H10N6O/c1-12(2)11-10-6-4(5(7)13)8-3-9-6/h3H,1-2H3,(H2,7,13)(H,8,9)/b11-10+
• InChI Key: FDKXTQMXEQVLRF-ZHACJKMWSA-N

詳細

アプリケーション

Dacarbazine is a triazine antineoplastic agent that is used for DNA methylation via formation of methyl adducts. It is used to treat metastatic malignant melanomas and Hodgkin′s when used in combination with other antineoplastic agents.

生物化学的／生理学的作用

Dacarbazine is a purine analog of naturally occurring purine precursor 5-amino-1H-imidazole-4-carboxamide (AIC). It is a synthetic triazine antineoplastic agent that exerts cytotoxic effects by acting as an alkylating agent and by inhibiting DNA synthesis and inducing apoptosis. It is known to induce hepatotoxicity in mice. Dacarbazine is not cell cycle-phase specific.

その他情報

Keep container tightly closed in a dry and well-ventilated place.

安全性情報

• ピクトグラム: GHS08,GHS07
• シグナルワード: Danger
• 危険有害性情報: H302 + H312 + H332,H315,H319,H335,H340,H350
• 注意書き: P280 - P301 + P312 - P302 + P352 + P312 - P304 + P340 + P312 - P305 + P351 + P338 - P308 + P313
• 危険有害性の分類: Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Carc. 1B - Eye Irrit. 2 - Muta. 1B - Skin Irrit. 2 - STOT SE 3
• ターゲットの組織: Respiratory system
• 保管分類コード: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable
• 個人用保護具 (PPE): Eyeshields, Gloves, type P3 (EN 143) respirator cartridges