D1446

デキスラゾキサン

≥95% (HPLC)

• 別名: (+)-(S)-4,4'-プロピレンジ-2,6-ピペラジンジオン, (S)-(+)-1,2-ビス(3,5-ジオキソピペラジン-1-イル)プロパン, ICRF-187, NSC169780, カルジオキサン, ジネカルド
• 実験式（ヒル表記法）: C₁₁H₁₆N₄O₄
• CAS番号: 24584-09-6
• 分子量: 268.27
• MDL番号: MFCD00866449
• UNSPSCコード: 12352200
• PubChem Substance ID: 329798699
• NACRES: NA.77

特性

• 品質水準: 100
• アッセイ: ≥95% (HPLC)
• フォーム: powder
• 色: white to off-white
• 溶解性: DMSO: >20 mg/mL
• オーガナイザー: Johnson & Johnson
• 保管温度: room temp
• SMILES記法: C[C@@H](CN1CC(=O)NC(=O)C1)N2CC(=O)NC(=O)C2
• InChI: 1S/C11H16N4O4/c1-7(15-5-10(18)13-11(19)6-15)2-14-3-8(16)12-9(17)4-14/h7H,2-6H2,1H3,(H,12,16,17)(H,13,18,19)/t7-/m0/s1
• InChI Key: BMKDZUISNHGIBY-ZETCQYMHSA-N

詳細

詳細

Dexrazoxane is a member of bis(2,6-dioxopiperazines), that functions as a topoisomerase 2 catalytic inhibitor. Dexrazoxane is a free radical scavenger. It might protect the heart from doxorubicin-associated damage. Dexrazoxane acts as a cardiopulmonary protectant, while treating Hodgkin′s disease (HD). It functions as a chelating agent, which limits the formation of anthracycline-iron complexes. It is used to synthesize antimalarial drugs.

アプリケーション

Dexrazoxane has been used in chromatin remodelling experiments.

生物化学的／生理学的作用

Dexrazoxane is a cardioprotective compound against anthracyclines. It functions by inhibiting topoisomerase II without inducing DNA strand breaks. Dexrazoxane is a + enantiomer of razoxane.

Dexrazoxane is a cardioprotective compound used to counteract the effects of anthracyclines. Dexrazoxane is believed to function as a free radical scanenger.

特徴および利点

This compound is a featured product for Apoptosis research. Click here to discover more featured Apoptosis products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound was developed by Johnson & Johnson. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

安全性情報

• ピクトグラム: GHS07
• シグナルワード: Warning
• 危険有害性情報: H315,H319,H335
• 注意書き: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• 危険有害性の分類: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• ターゲットの組織: Respiratory system
• 保管分類コード: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable