D0817

(−)-デグエリン

>98% (HPLC), powder

• 別名: (7aS,13aS)-13,13a-ジヒドロ-9,10-ジメトキシ-3,3-ジメチル-3H-ビス[1]ベンゾピラノ[3,4-b:6',5'-e]ピラン-7(7aH)-オン
• 実験式（ヒル表記法）: C₂₃H₂₂O₆
• CAS番号: 522-17-8
• 分子量: 394.42
• MDL番号: MFCD01740600
• UNSPSCコード: 12352200
• PubChem Substance ID: 329798641
• NACRES: NA.77

特性

• アッセイ: >98% (HPLC)
• 形状: powder
• 光学活性: [α]/D -70 to -80°, c = 0.2 in methanol
• 色: white to beige
• mp: 85-87 °C (lit.)
• 溶解性: DMSO: 10 mg/mL, clear
• 保管温度: −20°C
• SMILES記法: COc1cc2OC[C@H]3Oc4c(ccc5OC(C)(C)C=Cc45)C(=O)[C@H]3c2cc1OC
• InChI: 1S/C23H22O6/c1-23(2)8-7-12-15(29-23)6-5-13-21(24)20-14-9-17(25-3)18(26-4)10-16(14)27-11-19(20)28-22(12)13/h5-10,19-20H,11H2,1-4H3/t19-,20+/m1/s1
• InChI Key: ORDAZKGHSNRHTD-UXHICEINSA-N

詳細

アプリケーション

(−)-Deguelin has been used as:

• a nicotinamide adenine dinucleotide hydrogen (NADH) dehydrogenase (Complex I) inhibitor to study its effects on mitochondrial respiratory inhibition in human hepatocarcinoma cells (HepG2) and human renal proximal tubule epithelial cells (RPTECs)
• an antiviral compound to study inhibitory effects on human cytomegalovirus (HCMV)-infected human foreskin fibroblast (HFF) cells
• an analytical standard in high-performance liquid chromatography (HPLC)

生物化学的／生理学的作用

Deguelin is a natural rotenoid compound present abundantly in barks, leaves, seeds, and roots of the plants belonging to the Leguminosae family. Deguelin has been studied as a therapeutic agent against the skin, lung cancer, and mammary tumorigenesis.

活性化Aktインヒビタ-。MAPK、ERK1/2、JNKには作用しません。 抗がん薬, 化学予防薬。

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable
• 個人用保護具 (PPE): Eyeshields, Gloves, type N95 (US)