C9270

クーママイシンA1

• 別名: Notomycin A1
• 実験式（ヒル表記法）: C₅₅H₅₉N₅O₂₀
• CAS番号: 4434-05-3
• 分子量: 1110.08
• Beilstein: 470805
• MDL番号: MFCD00057312
• UNSPSCコード: 51102829
• PubChem Substance ID: 329775201
• NACRES: NA.85

特性

• 形状: powder
• 溶解性: DMSO: 50 mg/mL
• 抗生物質活性スペクトル: Gram-negative bacteria; Gram-positive bacteria
• 作用機序: DNA synthesis | interferes; enzyme | inhibits
• SMILES記法: CO[C@@H]1[C@@H](OC(=O)c2ccc(C)[nH]2)[C@@H](O)[C@H](Oc3ccc4C(O)=C(NC(=O)c5c[nH]c(C(=O)NC6=C(O)c7ccc(O[C@@H]8OC(C)(C)[C@H](OC)[C@@H](OC(=O)c9ccc(C)[nH]9)[C@H]8O)c(C)c7OC6=O)c5C)C(=O)Oc4c3C)OC1(C)C
• InChI: 1S/C55H59N5O20/c1-21-12-16-29(57-21)48(67)77-42-38(63)52(79-54(6,7)44(42)71-10)73-31-18-14-26-36(61)34(50(69)75-40(26)24(31)4)59-46(65)28-20-56-33(23(28)3)47(66)60-35-37(62)27-15-19-32(25(5)41(27)76-51(35)70)74-53-39(64)43(45(72-11)55(8,9)80-53)78-49(68)30-17-13-22(2)58-30/h12-20,38-39,42-45,52-53,56-58,61-64H,1-11H3,(H,59,65)(H,60,66)/t38-,39-,42+,43+,44-,45-,52-,53-/m1/s1
• InChI Key: WTIJXIZOODAMJT-DHFGXMAYSA-N

詳細

詳細

Chemical structure: coumarin-glycoside

アプリケーション

Coumermycin A1 is an aminocoumarin antibiotic used to study processes such as DNA replication, transcription, and recombination that involve DNA topoisomerase II activity. It has been used to treat Staphylococcus aureus endocarditis in the rat model and to study the effect of coumermycin A1 on the expression of 67 fusions in Salmonella typhimurium. .

生物化学的／生理学的作用

Coumermycin A1 inhibits DNA Gyrase which thereby inhibits cell division in bacteria.

その他情報

Keep container tightly closed in a dry and well-ventilated place. Keep in a dry place.

安全性情報

• ピクトグラム: GHS07
• シグナルワード: Warning
• 危険有害性情報: H302
• 注意書き: P264 - P270 - P301 + P312 - P501
• 危険有害性の分類: Acute Tox. 4 Oral
• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable
• 個人用保護具 (PPE): dust mask type N95 (US), Eyeshields, Gloves