C8093

Anti-Connexin 43 Antibody

mouse monoclonal, CXN-6

• 別名: Mouse monoclonal antibody
• MDL番号: MFCD00803532
• UNSPSCコード: 12352203
• NACRES: NA.41

特性

• product name: モノクロナール抗コネクシン-43 マウス宿主抗体, clone CXN-6, ascites fluid
• 由来生物: mouse
• 品質水準: 200
• 結合体: unconjugated
• 抗体製品の状態: ascites fluid
• 抗体製品タイプ: primary antibodies
• クローン: CXN-6, monoclonal
• 分子量: antigen 43 kDa
• 含みます: 15 mM sodium azide
• 化学種の反応性: rat, hamster, bovine, mouse, human
• テクニック: immunocytochemistry: suitable; immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable; immunohistochemistry (frozen sections): suitable; indirect ELISA: suitable; microarray: suitable; western blot: 1:8,000-1:16.000 using mouse whole brain extract
• アイソタイプ: IgM
• UniProtアクセッション番号: P17302
• 輸送温度: dry ice
• 保管温度: −20°C
• ターゲットの翻訳後修飾: unmodified
• 遺伝子情報: human ... GJA1(2697) , GJA1P1(2698) ; mouse ... Gja1(14609) ; rat ... Gja1(24392)

詳細

詳細

Monoclonal Anti-Connexin-43 (mouse IgM isotype) is derived from the CXN-6 hybridoma produced by the fusion of mouse myeloma cells and splenocytes from an immunized mouse. Connexin 43 (Cx43) is also known as GJA1 (gap junction protein alpha 1). The structure of connexin molecules includes a cytoplasmic N-terminal region, four transmembrane domains, two extracellular loops and a C-terminal cytoplasmic tail of varying length.

The 43 kDa connexin protein (connexin-43, Cx43) belongs to the a-type (group II) subfamily of connexin proteins. It is expressed in most tissues, even though the pattern of expression may differ in various cell types. For example, in the brain it is found in astrocytes, ependyma and leptomeninges but not in neurons, oligodendrocytes and pinealocytes; in the liver it is present in Ito cells but not hepatocytes.

特異性

Monoclonal Anti-Connexin-43 reacts specifically with connexin-43. Reactivity has been observed with human, bovine, hamster, rat, and mouse connexin-43.

免疫原

コネキシン-43のアミノ酸362~381に相当する合成ペプチド。

アプリケーション

Monoclonal Anti-Connexin-43 antibody produced in mouse has been used in:

• fluorescent immunostaining
• western blotting
• immunocytochemistry
• preparation of immuno-affinity columns

生物化学的／生理学的作用

Mutations in connexin 43 (Cx43) gene result in pleiotropic phenotype of oculodentodigital dysplasia. Connexin 43 participates in the multiplication and differentiation of mature T cells. It also participates in the secretion and manufacturing of cytokines. It helps to release lactate from glycolytic pancreatic ductal adenocarcinoma cells.

免責事項

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全性情報

• 保管分類コード: 13 - Non Combustible Solids
• WGK: WGK 1
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable