C7869

CEP-701 水和物

≥98% (HPLC)

• 別名: KT-5555 水和物, レスタウルチニブ 水和物
• 実験式（ヒル表記法）: C₂₆H₂₁N₃O₄ · xH₂O
• CAS番号: 111358-88-4
• 分子量: 439.46 (anhydrous basis)
• MDL番号: MFCD12828858
• UNSPSCコード: 12352200
• PubChem Substance ID: 329775153
• NACRES: NA.77

特性

• 品質水準: 100
• アッセイ: ≥98% (HPLC)
• フォーム: powder
• 色: white
• 溶解性: DMSO: >10 mg/mL
• 保管温度: −20°C
• SMILES記法: O.C[C@]12O[C@H](C[C@]1(O)CO)n3c4ccccc4c5c6C(=O)NCc6c7c8ccccc8n2c7c35
• InChI: 1S/C26H21N3O4.H2O/c1-25-26(32,12-30)10-18(33-25)28-16-8-4-2-6-13(16)20-21-15(11-27-24(21)31)19-14-7-3-5-9-17(14)29(25)23(19)22(20)28;/h2-9,18,30,32H,10-12H2,1H3,(H,27,31);1H2/t18-,25+,26+;/m1./s1
• InChI Key: LPOQWFBZBJTLEO-GMEYHWBASA-N

詳細

アプリケーション

CEP-701 hydrate has been used as a tyrosine kinase inhibitor:

• to study its effects on early growth response protein (EGR) genes and nerve growth factor (NGF) stimulation in human epithelial cells
• as a supplement in reservoir solution for co-crystallization studies with human receptor-interacting protein kinase 4 (RIPK4)
• as an FMS-like tyrosine kinase 3 (FLT3) inhibitor-gold nanoparticle conjugate to study its effects on acute myeloid leukemia

生物化学的／生理学的作用

CEP-701は、Flt-3レセプターチロシンキナーゼインヒビターです。

CEP-701 hydrate, also known as Lestaurtinib, can repress Janus kinase 2/signal transducer and activator of transcription 5 (JAK2/STAT5) signaling by the specific inhibition of JAK2.

特徴および利点

This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable
• 個人用保護具 (PPE): Eyeshields, Gloves, type N95 (US)