C7048

モノクロナール抗CD3 マウス宿主抗体

clone UCHT-1, purified immunoglobulin, buffered aqueous solution

• 別名: モノクロナール抗CD3
• UNSPSCコード: 12352203
• NACRES: NA.41

特性

• 由来生物: mouse
• 結合体: unconjugated
• 抗体製品の状態: purified immunoglobulin
• 抗体製品タイプ: primary antibodies
• クローン: UCHT-1, monoclonal
• フォーム: buffered aqueous solution
• 交差性: human
• テクニック: flow cytometry: 5 μL using 1 × 10⁶ cells
• アイソタイプ: IgG1
• UniProtアクセッション番号: P07766
• 輸送温度: wet ice
• 保管温度: 2-8°C
• ターゲットの翻訳後修飾: unmodified
• 遺伝子情報: human ... CD3E(916)

詳細

特異性

CD3複合体を認識します。クロ-ン番号UCHT-1のモノクロ-ナル抗体によって認識されるエピト-プは、CD3抗原/T細胞レセプタ-複合体のε鎖上に発現しています。3rd Workshop: code no. 126, 208 and 471
4th Workshop: paper no. T3.2

免疫原

ヒト胸腺細胞、セザリ-T細胞。

アプリケーション

Monoclonal Anti-CD3 antibody produced in mouse is suitable for flow cytometry at a dilution of 5μL using 1 × 10⁶ cells.

生物化学的／生理学的作用

The CD3e cytoplasmic domain of the T cell receptor binds to the inner leaflet of the plasma membrane (PM) and is accessible during early stages of T cell activation. It is specific for T lymphocytes, found in Purkinje cells of the cerebellum and gastric parietal cells of humans and other species. The antibodies commonly used to recognize CD3 are directed against the ε-subunit of the T cell receptor. Cytoplasmic cyCD3 expression can only be achieved during the early phase of NK-cell differentiation.

ターゲットの説明

CD3複合体(16/20/29/22/25~28 kDa)は、たがいに結合した5本のポリペプチド鎖からなり、T細胞レセプタ-と結合します。

物理的形状

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 1% bovine serum albumin and 15 mM sodium azide.

免責事項

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全性情報

• 保管分類コード: 10 - Combustible liquids
• WGK: nwg
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable