C6613

Anti-Cdc7 Kinase antibody, Mouse monoclonal

clone DCS-341, purified from hybridoma cell culture

• MDL番号: MFCD04975117
• UNSPSCコード: 12352203
• NACRES: NA.41

特性

• 由来生物: mouse
• 品質水準: 200
• 結合体: unconjugated
• 抗体製品の状態: purified immunoglobulin
• 抗体製品タイプ: primary antibodies
• クローン: DCS-341, monoclonal
• フォーム: buffered aqueous solution
• 化学種の反応性: human
• 濃度: ~2 mg/mL
• テクニック: immunocytochemistry: suitable; immunoprecipitation (IP): suitable; indirect ELISA: suitable; microarray: suitable; western blot: 0.4 μg/mL using total cell extract of A431 cells
• アイソタイプ: IgG1
• UniProtアクセッション番号: O00311
• 輸送温度: dry ice
• 保管温度: −20°C
• ターゲットの翻訳後修飾: unmodified
• 遺伝子情報: human ... CDC7(8317)

詳細

詳細

Anti-Cdc7 Kinase antibody, Mouse monoclonal (mouse IgG1 isotype) is derived from the DCS-341 hybridoma produced by the fusion of mouse myeloma cells (NS2) and splenocytes from BALB/c mice immunized with full length human Cdc7 kinase. Cell division cycle 7-related protein kinase(CDC7) is an enzyme encoded by the CDC7 gene in humans. It is highly expressed in diffuse large B cell lymphoma (DLBCL). Human Cdc7 kinase consists of 574 amino acids with a molecular weight of 55 kDa. CDC7 shares nearly 45% identity with yeast Cdc7 kinase in the kinase domain.

免疫原

full-length human Cdc7 kinase.

アプリケーション

Anti-Cdc7 Kinase antibody, Mouse monoclonal has been used in:

• enzyme-linked immunosorbent assay (ELISA)
• immunoblotting
• immunoprecipitation
• immunocytochemistry.

生物化学的／生理学的作用

Cell division cycle 7-related protein kinase (CDC7) in addition to its role in chromosome structure maintenance and repair, is also involved in meiosis and checkpoint responses.

Cell division cycle 7-related protein kinase(CDC7) is a serine-threonine essential kinase required for the initiation of DNA replication and is involved in regulation of the cell cycle. It is high expressed in diffuse large B cell lymphoma (DLBCL). Loss of Cdc7 kinase expression results in retarded growth at both cellular and whole body levels, with especially profound impairment of germ cell development. It inhibits genotoxin-induced apoptosis and increases survival in cancer cells. It may play an important role in the development and progression of colorectal cancer. Depletion of Cdc7 induces cancer cell death regardless of its p53 status. It can also interact with and phosphorylate Claspin.

物理的形状

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

免責事項

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全性情報

• 保管分類コード: 10 - Combustible liquids
• WGK: WGK 1
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable