C5366

二ヨウ化クロリソンダミン

≥98% (HPLC), white, solid

• 別名: 4,5,6,7-テトラクロロ-2,3-ジヒドロ-2-メチル-2-[2-(トリメチルアンモニオ)エチル]-2H-イソインドリウム二ヨウ化物
• 実験式（ヒル表記法）: C₁₄H₂₀Cl₄I₂N₂
• CAS番号: 96750-66-2
• 分子量: 611.94
• MDL番号: MFCD01074794
• UNSPSCコード: 12352116
• PubChem Substance ID: 24724443
• NACRES: NA.77

特性

• アッセイ: ≥98% (HPLC)
• 形状: solid
• 保管条件: protect from light
• 色: white
• 溶解性: H₂O: ≥2 mg/mL; DMSO: >20 mg/mL
• 保管温度: 2-8°C
• SMILES記法: [I-].[I-].C[N+](C)(C)CC[N+]1(C)Cc2c(Cl)c(Cl)c(Cl)c(Cl)c2C1
• InChI: 1S/C14H20Cl4N2.2HI/c1-19(2,3)5-6-20(4)7-9-10(8-20)12(16)14(18)13(17)11(9)15;;/h5-8H2,1-4H3;2*1H/q+2;;/p-2
• InChI Key: FPNVAOZHQUJJJQ-UHFFFAOYSA-L

詳細

アプリケーション

Chlorisondamine diiodide has been used:

• as a nicotinic receptor antagonist to test its effect on trinitrobenzene sulfonic acid (TNBS)-induced colitis
• as an irreversible nicotinic acetylcholine(nAChR) blocker to pre-treat brain samples to test its effect on cytochrome P450 2B (CYP2B) induction
• as a ganglionic blocker to test its effect on regulating corticosterone levels in rat with chronic stress

生物化学的／生理学的作用

Chlorisondamine diiodide mediates ganglionic and central blockade.

不可逆性かつ持続的に作用するニコチン性アセチルコリンレセプタ-のアンタゴニストです。

特徴および利点

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the Acetylcholine Receptors (Nicotinic) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

安全性情報

• ピクトグラム: GHS07,GHS09
• シグナルワード: Warning
• 危険有害性情報: H302,H400
• 注意書き: P273 - P301 + P312 + P330
• 危険有害性の分類: Acute Tox. 4 Oral - Aquatic Acute 1
• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 2
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable
• 個人用保護具 (PPE): dust mask type N95 (US), Eyeshields, Gloves