C3249

CR8

≥95% (HPLC)

• 別名: (2R)-2-[[9-(1-メチルエチル)-6-[[[4-(2-ピリジニル)フェニル]メチル]アミノ]-9H-プリン-2-イル]アミノ]-ブタノール-1, (R)-2-(1-ヒドロキシブタ-2-イルアミノ)-6-[4-(2-ピリジル)フェニルメチルアミノ]-9-イソ-プロピルプリン, C&R8
• 実験式（ヒル表記法）: C₂₄H₂₉N₇O
• CAS番号: 294646-77-8
• 分子量: 431.53
• MDL番号: MFCD18785641
• UNSPSCコード: 12352200
• PubChem Substance ID: 329775030
• NACRES: NA.77

特性

• 品質水準: 100
• アッセイ: ≥95% (HPLC)
• フォーム: powder
• 色: off-white
• 溶解性: DMSO: ≥10 mg/mL
• 保管温度: 2-8°C
• SMILES記法: CC[C@H](CO)Nc1nc(NCc2ccc(cc2)-c3ccccn3)c4ncn(C(C)C)c4n1
• InChI: 1S/C24H29N7O/c1-4-19(14-32)28-24-29-22(21-23(30-24)31(15-27-21)16(2)3)26-13-17-8-10-18(11-9-17)20-7-5-6-12-25-20/h5-12,15-16,19,32H,4,13-14H2,1-3H3,(H2,26,28,29,30)/t19-/m1/s1
• InChI Key: HOCBJBNQIQQQGT-LJQANCHMSA-N

詳細

生物化学的／生理学的作用

CR8はCDK1, CDK2, CDK5, CDK7, CDK9の強力な阻害剤です。

CR8 is a potent and selective inhibitor of cyclin dependent kinase (CDK1, 2, 5, 7, and 9). CR8 is a more potent pyridyl analogue of roscovitine (Cat. No. R7772). In comparison to roscovirtine, the compound gains in potency toward CK1, which is involved in amyloid-β formation. The R-CR8 enantiomer is slightly more potent than S. CR8 is around 30 times more potent at cellular assay then roscovitine. Acts as a molecular glue to induce cyclin K degradation.

特徴および利点

This compound is featured on the CDKs page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable